InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STMN2

Summary

InnateDB Gene

IDBG-26222.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STMN2

Gene Name

stathmin-like 2

Synonyms

SCG10; SCGN10

Species

Homo sapiens

Ensembl Gene

ENSG00000104435

Encoded Proteins

IDBP-26224

stathmin-like 2

IDBP-477102

stathmin-like 2

IDBP-475073

stathmin-like 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]
This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down\'s syndrome and Alzheimer\'s disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:79610814-79666175

Strand

Forward strand

Band

q21.13

Transcripts

ENST00000220876	ENSP00000220876
ENST00000518111	ENSP00000429243
ENST00000518491	ENSP00000430102

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	29 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0007026	negative regulation of microtubule depolymerization
GO:0010976	positive regulation of neuron projection development
GO:0010977	negative regulation of neuron projection development
GO:0031110	regulation of microtubule polymerization or depolymerization
GO:0031115	negative regulation of microtubule polymerization
GO:0031117	positive regulation of microtubule depolymerization
GO:1990090	cellular response to nerve growth factor stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030424	axon
GO:0030426	growth cone
GO:0031982	vesicle
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027500

View Gene Order

ENSBTAG00000020099

Not yet available

Cross-References

SwissProt

Q93045

TrEMBL

B7Z4N6 E5RGX5

UniProt Splice Variant

Entrez Gene

11075

UniGene

RefSeq

NM_007029 XM_005251142 NM_001199214

HUGO

HGNC:10577

OMIM

600621

CCDS

CCDS43748 CCDS56542

HPRD

09003

IMGT

EMBL

AC016240 AC025599 AK292737 AK297594 BC006302 BQ069488 BT020034 CH471068 CR456833 D50375 S82024

GenPept

AAB36428 AAH06302 AAV38837 BAA23326 BAF85426 BAH12622 CAG33114 EAW87064 EAW87065

RNA Seq Atlas

11075