InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FGD4

Summary

InnateDB Gene

IDBG-26267.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGD4

Gene Name

FYVE, RhoGEF and PH domain containing 4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000139132

Encoded Proteins

IDBP-238930

FYVE, RhoGEF and PH domain containing 4

IDBP-371544

FYVE, RhoGEF and PH domain containing 4

IDBP-598752

FYVE, RhoGEF and PH domain containing 4

IDBP-585574

FYVE, RhoGEF and PH domain containing 4

IDBP-584620

FYVE, RhoGEF and PH domain containing 4

IDBP-588974

FYVE, RhoGEF and PH domain containing 4

IDBP-600342

FYVE, RhoGEF and PH domain containing 4

IDBP-590943

FYVE, RhoGEF and PH domain containing 4

IDBP-603134

FYVE, RhoGEF and PH domain containing 4

IDBP-597197

FYVE, RhoGEF and PH domain containing 4

IDBP-717999

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:32399529-32646050

Strand

Forward strand

Band

p11.21

Transcripts

ENST00000395740	ENSP00000379089
ENST00000427716	ENSP00000394487
ENST00000472289	ENSP00000434356
ENST00000494275
ENST00000497153
ENST00000493087	ENSP00000437109
ENST00000473513
ENST00000479023
ENST00000494977	ENSP00000434062
ENST00000534526	ENSP00000449273
ENST00000550091
ENST00000531134	ENSP00000431323
ENST00000551984	ENSP00000449614
ENST00000546442	ENSP00000446695
ENST00000525053	ENSP00000433666
ENST00000583694	ENSP00000462623

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0031267	small GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007264	small GTPase mediated signal transduction
GO:0008360	regulation of cell shape
GO:0030032	lamellipodium assembly
GO:0030035	microspike assembly
GO:0030036	actin cytoskeleton organization
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043088	regulation of Cdc42 GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0046847	filopodium assembly
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway