Homo sapiens Gene: HOMER2
Summary
InnateDB Gene IDBG-26846.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOMER2
Gene Name homer homolog 2 (Drosophila)
Synonyms ACPD; CPD; HOMER-2; VESL-2;
Species Homo sapiens
Ensembl Gene ENSG00000103942
Encoded Proteins
homer homolog 2 (Drosophila)
homer homolog 2 (Drosophila)
homer homolog 2 (Drosophila)
homer homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:82836946-82986153
Strand Reverse strand
Band q25.2
Transcripts
ENST00000304231 ENSP00000305632
ENST00000450735 ENSP00000407634
ENST00000500334
ENST00000558090 ENSP00000452870
ENST00000558552
ENST00000558817 ENSP00000454125
ENST00000561345
ENST00000560374
ENST00000619367
ENST00000619240
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0030160 GKAP/Homer scaffold activity
GO:0035254 glutamate receptor binding
GO:0035256 G-protein coupled glutamate receptor binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007216 G-protein coupled glutamate receptor signaling pathway
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0048148 behavioral response to cocaine
GO:0048875 chemical homeostasis within a tissue
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0045177 apical part of cell
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.459142 Hs.729618 Hs.736981
RefSeq NM_004839 NM_199330 XM_005272448 XM_005272449 XM_006720776
HUGO
OMIM
CCDS CCDS45334 CCDS45336
HPRD 07269
IMGT
EMBL
GenPept
RNA Seq Atlas