InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HOMER2

Summary

InnateDB Gene

IDBG-26846.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOMER2

Gene Name

homer homolog 2 (Drosophila)

Synonyms

ACPD; CPD; HOMER-2; VESL-2

Species

Homo sapiens

Ensembl Gene

ENSG00000103942

Encoded Proteins

IDBP-26848

homer homolog 2 (Drosophila)

IDBP-379367

homer homolog 2 (Drosophila)

IDBP-596537

homer homolog 2 (Drosophila)

IDBP-596531

homer homolog 2 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:82836946-82986153

Strand

Reverse strand

Band

q25.2

Transcripts

ENST00000304231	ENSP00000305632
ENST00000450735	ENSP00000407634
ENST00000500334
ENST00000558090	ENSP00000452870
ENST00000558552
ENST00000558817	ENSP00000454125
ENST00000561345
ENST00000560374
ENST00000619367
ENST00000619240

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0030160	GKAP/Homer scaffold activity
GO:0035254	glutamate receptor binding
GO:0035256	G-protein coupled glutamate receptor binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007216	G-protein coupled glutamate receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0048148	behavioral response to cocaine
GO:0048875	chemical homeostasis within a tissue

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0045177	apical part of cell
GO:0045211	postsynaptic membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025813

View Gene Order

ENSBTAG00000017715

Not yet available

Cross-References

SwissProt

Q9NSB8

TrEMBL

UniProt Splice Variant

Entrez Gene

9455

UniGene

Hs.459142 Hs.729618 Hs.736981

RefSeq

NM_199330 XM_006720776 NM_004839 XM_005272448 XM_005272449

HUGO

HGNC:17513

OMIM

604799

CCDS

CCDS45334 CCDS45336

HPRD

07269

IMGT

EMBL

AC022558 AC044907 AF081530 AF093263 AF093264 BC012109 Y19025 Y19026 Y19027 Y19028

GenPept

AAC71027 AAC71028 AAD13748 AAH12109 CAB75537 CAB75538 CAB75539 CAB75540

RNA Seq Atlas

9455