Version 5.4
Homo sapiens Gene: CHMP4C
Summary
InnateDB Gene IDBG-26894.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHMP4C
Gene Name charged multivesicular body protein 4C
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164695
Encoded Proteins
IDBP-26896
charged multivesicular body protein 4C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:81732434-81759515
Strand Forward strand
Band q21.13
Transcripts
ENST00000297265 ENSP00000297265
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007034 vacuolar transport
GO:0009838 abscission
GO:0015031 protein transport
GO:0016032 viral process
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0031565 cytokinesis checkpoint
GO:0032466 negative regulation of cytokinesis
GO:0050792 regulation of viral process
GO:0061024 membrane organization
GO:1902188 positive regulation of viral release from host cell
Cellular Component
GO:0005829 cytosol
GO:0030496 midbody
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
GO:0090543 Flemming body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027536
View Gene Order
ENSBTAG00000004792
Not yet available
Pathways
NETPATH
REACTOME
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_27258
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_6359
Budding and maturation of HIV virion pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt Q96CF2
TrEMBL
UniProt Splice Variant
Entrez Gene 92421
UniGene Hs.183861 Hs.600810
RefSeq NM_152284
HUGO HGNC:30599
OMIM 610899
CCDS CCDS6233
HPRD 18135
IMGT
EMBL AB120734 AK314873 AY329086 BC014321 CH471068
GenPept AAH14321 AAQ91195 BAC87888 BAG37388 EAW87107
RNA Seq Atlas 92421

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca