Homo sapiens Gene: CDC37
Summary
InnateDB Gene IDBG-27267.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC37
Gene Name cell division cycle 37 homolog (S. cerevisiae)
Synonyms P50CDC37;
Species Homo sapiens
Ensembl Gene ENSG00000105401
Encoded Proteins
cell division cycle 37 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10391134-10420121
Strand Reverse strand
Band p13.2
Transcripts
ENST00000222005 ENSP00000222005
ENST00000589331 ENSP00000464889
ENST00000588498
ENST00000589755
ENST00000589625 ENSP00000465941
ENST00000589629 ENSP00000467747
ENST00000593124 ENSP00000465724
ENST00000588869 ENSP00000464971
ENST00000591248
ENST00000590632
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 273 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 273 [view]
Protein-Protein 272 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0031072 heat shock protein binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0043422 protein kinase B binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006605 protein targeting
GO:0051726 regulation of cell cycle
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032587 ruffle membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
AndrogenReceptor pathway
TNFalpha pathway
REACTOME
Signaling by EGFR in Cancer pathway
Signaling by constitutively active EGFR pathway
Signal Transduction pathway
Signaling by ERBB2 pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
LKB1 signaling events
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.160958 Hs.598118
RefSeq NM_007065
HUGO
OMIM
CCDS CCDS12237
HPRD 05456
IMGT
EMBL
GenPept
RNA Seq Atlas