InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: S1PR5

Summary

InnateDB Gene

IDBG-27610.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S1PR5

Gene Name

sphingosine-1-phosphate receptor 5

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000180739

Encoded Proteins

IDBP-27612

sphingosine-1-phosphate receptor 5

IDBP-371014

sphingosine-1-phosphate receptor 5

IDBP-763532

IDBP-806995

sphingosine-1-phosphate receptor 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:10512742-10517931

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000333430	ENSP00000328472
ENST00000439028	ENSP00000416915
ENST00000590601	ENSP00000464884
ENST00000617721	ENSP00000481239

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0038036	sphingosine-1-phosphate receptor activity

Biological Process

GO:0003376	sphingosine-1-phosphate signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0045664	regulation of neuron differentiation