Version 5.4
Homo sapiens Gene: SLC38A4
Summary
InnateDB Gene IDBG-28651.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC38A4
Gene Name solute carrier family 38, member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139209
Encoded Proteins
IDBP-28653
solute carrier family 38, member 4
IDBP-373150
solute carrier family 38, member 4
IDBP-598220
solute carrier family 38, member 4
IDBP-602157
solute carrier family 38, member 4
IDBP-592934
solute carrier family 38, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:46764761-46832408
Strand Reverse strand
Band q13.11
Transcripts
ENST00000266579 ENSP00000266579
ENST00000447411 ENSP00000389843
ENST00000550670 ENSP00000448186
ENST00000547477 ENSP00000450071
ENST00000546940 ENSP00000448543
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015171 amino acid transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006865 amino acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022464
View Gene Order
ENSBTAG00000014197
Not yet available
Pathways
NETPATH
REACTOME
REACT_13796
Amino acid transport across the plasma membrane pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.446077 Hs.694012
RefSeq NM_001143824 NM_018018 XM_005268997
HUGO
OMIM
CCDS CCDS8750
HPRD 12159
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca