Homo sapiens Gene: SMURF1
Summary
InnateDB Gene IDBG-28871.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMURF1
Gene Name SMAD specific E3 ubiquitin protein ligase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198742
Encoded Proteins
SMAD specific E3 ubiquitin protein ligase 1
SMAD specific E3 ubiquitin protein ligase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:99027438-99144100
Strand Reverse strand
Band q22.1
Transcripts
ENST00000361125 ENSP00000354621
ENST00000361368 ENSP00000355326
ENST00000480055
ENST00000472627
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 441 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 441 [view]
Protein-Protein 433 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 8 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0048185 activin binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006611 protein export from nucleus
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007398 ectoderm development
GO:0016567 protein ubiquitination
GO:0030154 cell differentiation
GO:0030279 negative regulation of ossification
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030579 ubiquitin-dependent SMAD protein catabolic process
GO:0032801 receptor catabolic process
GO:0034394 protein localization to cell surface
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030424 axon
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
PCP/CE pathway pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
beta-catenin independent WNT signaling pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by Wnt pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Downregulation of TGF-beta receptor signaling pathway
Asymmetric localization of PCP proteins pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Class I MHC mediated antigen processing & presentation pathway
Signaling by BMP pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
TGF-beta receptor signaling activates SMADs pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
KEGG
Ubiquitin mediated proteolysis pathway
Endocytosis pathway
TGF-beta signaling pathway pathway
INOH
TGF-beta signaling pathway
PID BIOCARTA
Estrogen responsive protein efp controls cell cycle and breast tumors growth [Biocarta view]
PID NCI
BMP receptor signaling
Signaling events mediated by HDAC Class I
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.189329 Hs.595162
RefSeq NM_001199847 NM_020429 NM_181349 XM_005250507 XM_006716061
HUGO
OMIM
CCDS CCDS34689 CCDS34690
HPRD 06902
IMGT
EMBL
GenPept
RNA Seq Atlas