InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NDEL1

Summary

InnateDB Gene

IDBG-29031.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDEL1

Gene Name

nudE nuclear distribution E homolog (A. nidulans)-like 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000166579

Encoded Proteins

IDBP-29035

nudE nuclear distribution gene E homolog (A. nidulans)-like 1

IDBP-29037

nudE nuclear distribution gene E homolog (A. nidulans)-like 1

IDBP-294390

nudE nuclear distribution gene E homolog (A. nidulans)-like 1

IDBP-763490

IDBP-764554

IDBP-764025

IDBP-759775

IDBP-758708

IDBP-763860

IDBP-757870

IDBP-764594

IDBP-764103

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:8413131-8490411

Strand

Forward strand

Band

p13.1

Transcripts

ENST00000334527	ENSP00000333982
ENST00000380025	ENSP00000369364
ENST00000402554	ENSP00000384963
ENST00000580237	ENSP00000464154
ENST00000580738
ENST00000580012	ENSP00000463351
ENST00000579150
ENST00000582277	ENSP00000464441
ENST00000582490	ENSP00000462759
ENST00000583066
ENST00000582665	ENSP00000463430
ENST00000579880
ENST00000583683
ENST00000582812	ENSP00000462052
ENST00000581189
ENST00000584866	ENSP00000462458
ENST00000578172
ENST00000581679	ENSP00000464634
ENST00000585098	ENSP00000463492

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	61 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0032403	protein complex binding
GO:0043014	alpha-tubulin binding
GO:0048487	beta-tubulin binding
GO:0070012	oligopeptidase activity

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0001764	neuron migration
GO:0001833	inner cell mass cell proliferation
GO:0006508	proteolysis
GO:0007059	chromosome segregation
GO:0007100	mitotic centrosome separation
GO:0008090	retrograde axon cargo transport
GO:0010975	regulation of neuron projection development
GO:0016477	cell migration
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021955	central nervous system neuron axonogenesis
GO:0031175	neuron projection development
GO:0032864	activation of Cdc42 GTPase activity
GO:0045773	positive regulation of axon extension
GO:0047496	vesicle transport along microtubule
GO:0048680	positive regulation of axon regeneration
GO:0051081	nuclear envelope disassembly
GO:0051642	centrosome localization
GO:0060052	neurofilament cytoskeleton organization
GO:1990138	neuron projection extension

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005635	nuclear envelope
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0030424	axon
GO:0031252	cell leading edge
GO:0043203	axon hillock
GO:0044297	cell body
GO:0060053	neurofilament cytoskeleton