Version 5.4
Homo sapiens Gene: STX8
Summary
InnateDB Gene IDBG-29710.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STX8
Gene Name syntaxin 8
Synonyms CARB
Species Homo sapiens
Ensembl Gene ENSG00000170310
Encoded Proteins
IDBP-29712
syntaxin 8
IDBP-761055
IDBP-759497
IDBP-763803
IDBP-763131
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:9250471-9576591
Strand Reverse strand
Band p13.1
Transcripts
ENST00000306357 ENSP00000305255
ENST00000570583
ENST00000575294 ENSP00000468093
ENST00000574382
ENST00000574431 ENSP00000467749
ENST00000573016 ENSP00000460073
ENST00000573881
ENST00000570987
ENST00000574775
ENST00000573077
ENST00000575858 ENSP00000460355
ENST00000573373
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005484 SNAP receptor activity
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006906 vesicle fusion
GO:0008333 endosome to lysosome transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005887 integral component of plasma membrane
GO:0031201 SNARE complex
GO:0031902 late endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020903
View Gene Order
ENSBTAG00000017815
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04130
SNARE interactions in vesicular transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004853
HUGO
OMIM
CCDS CCDS32565
HPRD 05012
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca