Version 5.4
Homo sapiens Gene: ZNF423
Summary
InnateDB Gene IDBG-30289.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF423
Gene Name zinc finger protein 423
Synonyms Ebfaz; JBTS19; NPHP14; OAZ; Roaz; Zfp104; ZFP423
Species Homo sapiens
Ensembl Gene ENSG00000102935
Encoded Proteins
IDBP-30291
zinc finger protein 423
IDBP-600576
zinc finger protein 423
IDBP-747117
IDBP-751611
IDBP-748617
IDBP-751820
IDBP-745755
IDBP-812283
zinc finger protein 423
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25554785
[Mus musculus] The transcription factor Zfp423 is necessary for adipocyte activation and impaired adipogenesis is observed in Zfp423(nur12) mice.
Entrez Gene
Summary The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:49487524-49857919
Strand Reverse strand
Band q12.1
Transcripts
ENST00000262383 ENSP00000262383
ENST00000535559 ENSP00000442321
ENST00000567169 ENSP00000455061
ENST00000561648 ENSP00000455426
ENST00000562520 ENSP00000457664
ENST00000563137 ENSP00000455588
ENST00000562871 ENSP00000457928
ENST00000568094 ENSP00000479288
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007219 Notch signaling pathway
GO:0007399 nervous system development
GO:0030154 cell differentiation
GO:0030513 positive regulation of BMP signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045333
View Gene Order
ENSBTAG00000017397
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
BMP2 signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.443715 Hs.530930 Hs.617541
RefSeq NM_001271620 NM_015069 XM_005255855 XM_005255856 XM_005255857 XM_006721171
HUGO
OMIM
CCDS CCDS32445 CCDS61930
HPRD 05189
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca