Version 5.4
Homo sapiens Gene: PARG
Summary
InnateDB Gene IDBG-304161.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARG
Gene Name poly (ADP-ribose) glycohydrolase
Synonyms PARG99
Species Homo sapiens
Ensembl Gene ENSG00000227345
Encoded Proteins
IDBP-293351
poly (ADP-ribose) glycohydrolase
IDBP-813334
poly (ADP-ribose) glycohydrolase
IDBP-813336
poly (ADP-ribose) glycohydrolase
IDBP-813342
poly (ADP-ribose) glycohydrolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. [provided by RefSeq, Jul 2008]
Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:49818279-49970203
Strand Reverse strand
Band q11.23
Transcripts
ENST00000402038 ENSP00000384408
ENST00000492350
ENST00000497481
ENST00000614063 ENSP00000480645
ENST00000610922 ENSP00000481064
ENST00000616448 ENSP00000484285
ENST00000611974
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004649 poly(ADP-ribose) glycohydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0016045 detection of bacterium
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021911
View Gene Order
ENSBTAG00000023018
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.535298 Hs.595360 Hs.732225
RefSeq NM_003631
HUGO
OMIM
CCDS CCDS73130
HPRD 04611
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca