Version 5.4
Homo sapiens Gene: RIC3
Summary
InnateDB Gene IDBG-30545.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RIC3
Gene Name resistance to inhibitors of cholinesterase 3 homolog (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166405
Encoded Proteins
IDBP-30547
resistance to inhibitors of cholinesterase 3 homolog (C. elegans)
IDBP-30549
resistance to inhibitors of cholinesterase 3 homolog (C. elegans)
IDBP-30551
resistance to inhibitors of cholinesterase 3 homolog (C. elegans)
IDBP-365369
resistance to inhibitors of cholinesterase 3 homolog (C. elegans)
IDBP-365371
resistance to inhibitors of cholinesterase 3 homolog (C. elegans)
IDBP-592494
resistance to inhibitors of cholinesterase 3 homolog (C. elegans)
IDBP-585104
resistance to inhibitors of cholinesterase 3 homolog (C. elegans)
IDBP-600430
resistance to inhibitors of cholinesterase 3 homolog (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene promotes functional expression of homomeric nicotinic acetylcholine receptors at the cell surface. It enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:8106093-8169055
Strand Reverse strand
Band p15.4
Transcripts
ENST00000335425 ENSP00000333988
ENST00000309737 ENSP00000308820
ENST00000343202 ENSP00000344904
ENST00000425599 ENSP00000395320
ENST00000419822 ENSP00000404415
ENST00000526962 ENSP00000434787
ENST00000524799
ENST00000530060
ENST00000528463 ENSP00000435244
ENST00000531450 ENSP00000431658
ENST00000529271
ENST00000529035
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0033130 acetylcholine receptor binding
GO:0044183 protein binding involved in protein folding
Biological Process
GO:0006457 protein folding
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007271 synaptic transmission, cholinergic
GO:0043623 cellular protein complex assembly
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048330
View Gene Order
ENSBTAG00000004863
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.231850
RefSeq NM_001135109 NM_001206671 NM_001206672 NM_024557 XM_006718318
HUGO
OMIM
CCDS CCDS44533 CCDS55741 CCDS55742 CCDS7788
HPRD 17974
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca