Version 5.4
Homo sapiens Gene: RAP1GDS1
Summary
InnateDB Gene IDBG-30852.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAP1GDS1
Gene Name RAP1, GTP-GDP dissociation stimulator 1
Synonyms GDS1; SmgGDS
Species Homo sapiens
Ensembl Gene ENSG00000138698
Encoded Proteins
IDBP-30854
RAP1, GTP-GDP dissociation stimulator 1
IDBP-30856
RAP1, GTP-GDP dissociation stimulator 1
IDBP-30858
RAP1, GTP-GDP dissociation stimulator 1
IDBP-295725
RAP1, GTP-GDP dissociation stimulator 1
IDBP-295722
RAP1, GTP-GDP dissociation stimulator 1
IDBP-374692
RAP1, GTP-GDP dissociation stimulator 1
IDBP-473805
RAP1, GTP-GDP dissociation stimulator 1
IDBP-479884
RAP1, GTP-GDP dissociation stimulator 1
IDBP-481427
RAP1, GTP-GDP dissociation stimulator 1
IDBP-475207
RAP1, GTP-GDP dissociation stimulator 1
IDBP-475713
RAP1, GTP-GDP dissociation stimulator 1
IDBP-473492
RAP1, GTP-GDP dissociation stimulator 1
IDBP-473424
RAP1, GTP-GDP dissociation stimulator 1
IDBP-476308
RAP1, GTP-GDP dissociation stimulator 1
IDBP-813646
RAP1, GTP-GDP dissociation stimulator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:98261384-98443861
Strand Forward strand
Band q23
Transcripts
ENST00000339360 ENSP00000340454
ENST00000380158 ENSP00000369503
ENST00000264572 ENSP00000264572
ENST00000408927 ENSP00000386153
ENST00000408900 ENSP00000386223
ENST00000453712 ENSP00000407157
ENST00000509011 ENSP00000425992
ENST00000503667 ENSP00000422348
ENST00000508490 ENSP00000422426
ENST00000505378
ENST00000508213 ENSP00000426096
ENST00000512857
ENST00000511379
ENST00000514122 ENSP00000424324
ENST00000515187
ENST00000510870 ENSP00000424250
ENST00000511212 ENSP00000421599
ENST00000507303
ENST00000503745
ENST00000509501 ENSP00000421482
ENST00000514139 ENSP00000475933
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005488 binding
GO:0005515 protein binding
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0014829 vascular smooth muscle contraction
GO:0015991 ATP hydrolysis coupled proton transport
GO:0031034 myosin filament assembly
GO:0032321 positive regulation of Rho GTPase activity
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0051561 positive regulation of mitochondrial calcium ion concentration
Cellular Component
GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028149
View Gene Order
ENSBTAG00000007522
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
Cross-References
SwissProt
TrEMBL D6RHH8
UniProt Splice Variant
Entrez Gene 5910
UniGene Hs.132858 Hs.701182
RefSeq NM_001100426 NM_001100427 NM_001100428 NM_001100429 NM_001100430 NM_021159 XM_006714284
HUGO HGNC:9859
OMIM 179502
CCDS CCDS43253 CCDS43254 CCDS47105 CCDS47106 CCDS47107 CCDS47108
HPRD 11763
IMGT
EMBL AC019077 AC058823 AC078961
GenPept
RNA Seq Atlas 5910

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca