Version 5.4
Homo sapiens Gene: WEE1
Summary
InnateDB Gene IDBG-31415.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WEE1
Gene Name WEE1 homolog (S. pombe)
Synonyms WEE1A; WEE1hu
Species Homo sapiens
Ensembl Gene ENSG00000166483
Encoded Proteins
IDBP-31417
WEE1 homolog (S. pombe)
IDBP-366015
WEE1 homolog (S. pombe)
IDBP-602336
WEE1 homolog (S. pombe)
IDBP-594934
WEE1 homolog (S. pombe)
IDBP-603096
WEE1 homolog (S. pombe)
IDBP-589215
WEE1 homolog (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:9573681-9593457
Strand Forward strand
Band p15.4
Transcripts
ENST00000299613 ENSP00000299613
ENST00000450114 ENSP00000402084
ENST00000524549
ENST00000524612 ENSP00000434446
ENST00000530712 ENSP00000434148
ENST00000530175 ENSP00000435945
ENST00000532275
ENST00000527848 ENSP00000432284
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated
Total 38 [view]
Protein-Protein 36 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007067 mitotic nuclear division
GO:0007596 blood coagulation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030010 establishment of cell polarity
GO:0048812 neuron projection morphogenesis
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031016
View Gene Order
ENSBTAG00000005278
Not yet available
Pathways
NETPATH
REACTOME
REACT_1846
G2/M DNA replication checkpoint pathway
REACT_407
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway
REACT_897
G2/M DNA damage checkpoint pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_1006
Polo-like kinase mediated events pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_604
Hemostasis pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04110
Cell cycle pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.249441
RefSeq NM_001143976 NM_003390
HUGO
OMIM
CCDS CCDS44536 CCDS7800
HPRD 01907
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca