InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SCAP

Summary

InnateDB Gene

IDBG-31555.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCAP

Gene Name

SREBF chaperone

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000114650

Encoded Proteins

IDBP-31557

SREBF chaperone

IDBP-31559

SREBF chaperone

IDBP-375272

SREBF chaperone

IDBP-375289

SREBF chaperone

IDBP-375290

SREBF chaperone

IDBP-375293

SREBF chaperone

IDBP-375299

SREBF chaperone

IDBP-483357

SREBF chaperone

IDBP-586492

SREBF chaperone

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:47413694-47477126

Strand

Reverse strand

Band

p21.31

Transcripts

ENST00000265565	ENSP00000265565
ENST00000320017	ENSP00000324296
ENST00000441517	ENSP00000416847
ENST00000416208	ENSP00000409183
ENST00000428413	ENSP00000401819
ENST00000416847	ENSP00000408102
ENST00000420588
ENST00000448217	ENSP00000415195
ENST00000465628
ENST00000468965
ENST00000494938
ENST00000487942
ENST00000495603	ENSP00000423419
ENST00000485967
ENST00000545718	ENSP00000438956

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008158	hedgehog receptor activity
GO:0032403	protein complex binding
GO:0051082	unfolded protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0007568	aging
GO:0008203	cholesterol metabolic process
GO:0019217	regulation of fatty acid metabolic process
GO:0032868	response to insulin
GO:0032933	SREBP signaling pathway
GO:0042304	regulation of fatty acid biosynthetic process
GO:0044281	small molecule metabolic process
GO:0045540	regulation of cholesterol biosynthetic process
GO:0045541	negative regulation of cholesterol biosynthetic process
GO:0045716	positive regulation of low-density lipoprotein particle receptor biosynthetic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032485

View Gene Order

ENSBTAG00000015782

Not yet available

Pathways

NETPATH

REACTOME

REACT_147797

Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q12770

TrEMBL

C9JFY0 C9JQ35 D6RA39 F8W921 F8W9W7 F8WDP3 F8WEH8

UniProt Splice Variant

Entrez Gene

22937

UniGene

Hs.531789 Hs.614893

RefSeq

NM_012235 XM_005264967 XM_005264968 XM_005264969 XM_005264970 XM_005264972 XM_006713034

HUGO

HGNC:30634

OMIM

601510

CCDS

CCDS2755

HPRD

IMGT

EMBL

AC099778 AK027402 AK075528 BC020987 D83782

GenPept

AAH20987 BAA12111 BAB55088 BAC11673

RNA Seq Atlas

22937