Homo sapiens Gene: SCAP
Summary
InnateDB Gene IDBG-31555.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCAP
Gene Name SREBF chaperone
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000114650
Encoded Proteins
SREBF chaperone
SREBF chaperone
SREBF chaperone
SREBF chaperone
SREBF chaperone
SREBF chaperone
SREBF chaperone
SREBF chaperone
SREBF chaperone
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:47413694-47477126
Strand Reverse strand
Band p21.31
Transcripts
ENST00000265565 ENSP00000265565
ENST00000320017 ENSP00000324296
ENST00000441517 ENSP00000416847
ENST00000416208 ENSP00000409183
ENST00000428413 ENSP00000401819
ENST00000416847 ENSP00000408102
ENST00000420588
ENST00000448217 ENSP00000415195
ENST00000465628
ENST00000468965
ENST00000494938
ENST00000487942
ENST00000495603 ENSP00000423419
ENST00000485967
ENST00000545718 ENSP00000438956
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008158 hedgehog receptor activity
GO:0032403 protein complex binding
GO:0051082 unfolded protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0007568 aging
GO:0008203 cholesterol metabolic process
GO:0019217 regulation of fatty acid metabolic process
GO:0032868 response to insulin
GO:0032933 SREBP signaling pathway
GO:0042304 regulation of fatty acid biosynthetic process
GO:0044281 small molecule metabolic process
GO:0045540 regulation of cholesterol biosynthetic process
GO:0045541 negative regulation of cholesterol biosynthetic process
GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Metabolism pathway
KEGG
INOH
PID BIOCARTA
Srebp control of lipid synthesis [Biocarta view]
PID NCI
Cross-References
SwissProt Q12770
TrEMBL C9JQ35 D6RA39 F8W921
UniProt Splice Variant
Entrez Gene 22937
UniGene Hs.531789 Hs.614893
RefSeq NM_012235 XM_005264967 XM_006713034 XM_005264972 XM_005264970 XM_005264969 XM_005264968
HUGO HGNC:30634
OMIM 601510
CCDS CCDS2755
HPRD 03300
IMGT
EMBL AC099778 AK027402 AK075528 BC020987 D83782
GenPept AAH20987 BAA12111 BAB55088 BAC11673
RNA Seq Atlas 22937