Homo sapiens Gene: CES5A
Summary
InnateDB Gene IDBG-31642.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CES5A
Gene Name carboxylesterase 5A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159398
Encoded Proteins
carboxylesterase 5A
carboxylesterase 5A
carboxylesterase 5A
carboxylesterase 5A
carboxylesterase 5A
carboxylesterase 5A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:55846154-55956031
Strand Reverse strand
Band q12.2
Transcripts
ENST00000319165 ENSP00000324271
ENST00000290567 ENSP00000290567
ENST00000521992 ENSP00000428864
ENST00000521228 ENSP00000461804
ENST00000518005 ENSP00000428571
ENST00000520435 ENSP00000428887
ENST00000541580
ENST00000544479 ENSP00000461117
ENST00000536025 ENSP00000439810
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL F5H0J7
UniProt Splice Variant
Entrez Gene 221223
UniGene Hs.350800
RefSeq NM_145024 NM_001190158 NM_001143685 XM_005276868 XM_005255841
HUGO HGNC:26459
OMIM
CCDS CCDS10755 CCDS54012 CCDS45490
HPRD 07016
IMGT
EMBL AC007335 AC147362
GenPept
RNA Seq Atlas 221223