Homo sapiens Gene: ASB7
Summary
InnateDB Gene IDBG-32097.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASB7
Gene Name ankyrin repeat and SOCS box containing 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183475
Encoded Proteins
ankyrin repeat and SOCS box containing 7
ankyrin repeat and SOCS box containing 7
ankyrin repeat and SOCS box containing 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:100602534-100651705
Strand Forward strand
Band q26.3
Transcripts
ENST00000343276 ENSP00000339819
ENST00000332783 ENSP00000328327
ENST00000558747 ENSP00000453626
ENST00000561192
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H0YMJ1
UniProt Splice Variant
Entrez Gene 140460
UniGene Hs.31845 Hs.708403
RefSeq NM_024708 NM_198243
HUGO HGNC:17182
OMIM 615052
CCDS CCDS10388 CCDS10387
HPRD 10674
IMGT
EMBL AC090695
GenPept
RNA Seq Atlas 140460