Version 5.4
Homo sapiens Gene: RSPO2
Summary
InnateDB Gene IDBG-32363.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RSPO2
Gene Name R-spondin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147655
Encoded Proteins
IDBP-32365
R-spondin 2
IDBP-482155
R-spondin 2
IDBP-480144
R-spondin 2
IDBP-477312
R-spondin 2
IDBP-479182
R-spondin 2
IDBP-474330
R-spondin 2
IDBP-479532
R-spondin 2
IDBP-477682
R-spondin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:107899316-108083648
Strand Reverse strand
Band q23.1
Transcripts
ENST00000276659 ENSP00000276659
ENST00000517939 ENSP00000428940
ENST00000517781 ENSP00000427937
ENST00000521502 ENSP00000428614
ENST00000521757 ENSP00000430485
ENST00000521956 ENSP00000430010
ENST00000520026 ENSP00000429159
ENST00000522333 ENSP00000430973
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0008201 heparin binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0016055 Wnt signaling pathway
GO:0030282 bone mineralization
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0060437 lung growth
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060535 trachea cartilage morphogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051920
View Gene Order
ENSBTAG00000013598
Not yet available
Pathways
NETPATH
NetPath_8
Wnt pathway
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200716
regulation of FZD by ubiquitination pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444834
RefSeq NM_001282863 NM_178565 XM_005250906 XM_005250907
HUGO
OMIM
CCDS CCDS6307 CCDS64953
HPRD 17536
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca