Version 5.4
Homo sapiens Gene: GDF7
Summary
InnateDB Gene IDBG-32594.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GDF7
Gene Name growth differentiation factor 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143869
Encoded Proteins
IDBP-32596
growth differentiation factor 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-beta superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:20666664-20673658
Strand Forward strand
Band p24.1
Transcripts
ENST00000272224 ENSP00000272224
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0007411 axon guidance
GO:0010628 positive regulation of gene expression
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0021509 roof plate formation
GO:0021527 spinal cord association neuron differentiation
GO:0021915 neural tube development
GO:0022612 gland morphogenesis
GO:0030509 BMP signaling pathway
GO:0030855 epithelial cell differentiation
GO:0030901 midbrain development
GO:0032924 activin receptor signaling pathway
GO:0040007 growth
GO:0045165 cell fate commitment
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048608 reproductive structure development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048853 forebrain morphogenesis
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060571 morphogenesis of an epithelial fold
GO:2001051 positive regulation of tendon cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037660
View Gene Order
ENSBTAG00000038224
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
Cross-References
SwissProt Q7Z4P5
TrEMBL Q75RY1
UniProt Splice Variant
Entrez Gene 151449
UniGene Hs.447688
RefSeq NM_182828
HUGO HGNC:4222
OMIM 604651
CCDS CCDS1701
HPRD
IMGT
EMBL AB158468 AC012065 AF522369
GenPept AAP97720 BAD07014
RNA Seq Atlas 151449

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca