InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AP1S1

Summary

InnateDB Gene

IDBG-33022.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP1S1

Gene Name

adaptor-related protein complex 1, sigma 1 subunit

Synonyms

AP19; CLAPS1; EKV3; MEDNIK; SIGMA1A; WUGSC:H_DJ0747G18.2

Species

Homo sapiens

Ensembl Gene

ENSG00000106367

Encoded Proteins

IDBP-33024

adaptor-related protein complex 1, sigma 1 subunit

IDBP-384124

adaptor-related protein complex 1, sigma 1 subunit

IDBP-384126

adaptor-related protein complex 1, sigma 1 subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:101154397-101161596

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000337619	ENSP00000336666
ENST00000443943	ENSP00000410780
ENST00000429457	ENSP00000399902

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0006898	receptor-mediated endocytosis
GO:0009615	response to virus
GO:0015031	protein transport
GO:0016032	viral process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0050690	regulation of defense response to virus by virus
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0005905	coated pit
GO:0016020	membrane
GO:0030121	AP-1 adaptor complex
GO:0030659	cytoplasmic vesicle membrane
GO:0032588	trans-Golgi network membrane
GO:0070062	extracellular vesicular exosome