Mus musculus Gene: Ap1s1
Summary
InnateDB Gene IDBG-204780.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ap1s1
Gene Name adaptor protein complex AP-1, sigma 1
Synonyms AP19;
Species Mus musculus
Ensembl Gene ENSMUSG00000004849
Encoded Proteins
adaptor protein complex AP-1, sigma 1
adaptor protein complex AP-1, sigma 1
adaptor protein complex AP-1, sigma 1
adaptor protein complex AP-1, sigma 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106367:
The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:137034993-137046135
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000111080 ENSMUSP00000106709
ENSMUST00000154183
ENSMUST00000150603 ENSMUSP00000115941
ENSMUST00000144303 ENSMUSP00000120895
ENSMUST00000129356 ENSMUSP00000119458
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008565 protein transporter activity
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0009615 response to virus
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005802 trans-Golgi network
GO:0005905 coated pit
GO:0016020 membrane
GO:0030117 membrane coat
GO:0030121 AP-1 adaptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Membrane Trafficking pathway
Lysosome Vesicle Biogenesis pathway
Immune System pathway
Golgi Associated Vesicle Biogenesis pathway
MHC class II antigen presentation pathway
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
Adaptive Immune System pathway
KEGG
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
MHC class II antigen presentation pathway
trans-Golgi Network Vesicle Budding pathway
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
Adaptive Immune System pathway
Clathrin derived vesicle budding pathway
Immune System pathway
Golgi Associated Vesicle Biogenesis pathway
HIV Infection pathway
Lysosome Vesicle Biogenesis pathway
Nef mediated downregulation of MHC class I complex cell surface expression pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Host Interactions of HIV factors pathway
Disease pathway
Membrane Trafficking pathway
Golgi Associated Vesicle Biogenesis pathway
Immune System pathway
Clathrin derived vesicle budding pathway
MHC class II antigen presentation pathway
trans-Golgi Network Vesicle Budding pathway
Adaptive Immune System pathway
Lysosome Vesicle Biogenesis pathway
Membrane Trafficking pathway
KEGG
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D3Z268
UniProt Splice Variant
Entrez Gene 11769
UniGene Mm.833
RefSeq NM_007457 XM_006504348 XM_006504347
OMIM
CCDS CCDS39330
HPRD
IMGT
MGI ID MGI:1098244
MGI Symbol Ap1s1
EMBL AC147986
GenPept
RNA Seq Atlas 11769