Homo sapiens Gene: LEF1
Summary
InnateDB Gene IDBG-33529.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LEF1
Gene Name lymphoid enhancer-binding factor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138795
Encoded Proteins
lymphoid enhancer-binding factor 1
lymphoid enhancer-binding factor 1
lymphoid enhancer-binding factor 1
lymphoid enhancer-binding factor 1
lymphoid enhancer-binding factor 1
lymphoid enhancer-binding factor 1
lymphoid enhancer-binding factor 1
lymphoid enhancer-binding factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:108047545-108168956
Strand Reverse strand
Band q25
Transcripts
ENST00000265165 ENSP00000265165
ENST00000379951 ENSP00000369284
ENST00000438313 ENSP00000406176
ENST00000503879
ENST00000504426
ENST00000505379
ENST00000514444
ENST00000505297
ENST00000510135
ENST00000507470
ENST00000509428
ENST00000512407
ENST00000510624 ENSP00000422840
ENST00000506680 ENSP00000422334
ENST00000505328
ENST00000504775
ENST00000504950 ENSP00000427459
ENST00000515500 ENSP00000422801
ENST00000510717
ENST00000512172 ENSP00000427365
ENST00000505293
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 68 [view]
Protein-Protein 59 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0030284 estrogen receptor activity
GO:0030331 estrogen receptor binding
GO:0035326 enhancer binding
GO:0042393 histone binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0045295 gamma-catenin binding
GO:0070016 armadillo repeat domain binding
GO:0070742 C2H2 zinc finger domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001569 patterning of blood vessels
GO:0001649 osteoblast differentiation
GO:0001755 neural crest cell migration
GO:0001756 somitogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0001944 vasculature development
GO:0002040 sprouting angiogenesis
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016055 Wnt signaling pathway
GO:0016202 regulation of striated muscle tissue development
GO:0021542 dentate gyrus development
GO:0021766 hippocampus development
GO:0021854 hypothalamus development
GO:0021861 forebrain radial glial cell differentiation
GO:0021873 forebrain neuroblast division
GO:0021879 forebrain neuron differentiation
GO:0021943 formation of radial glial scaffolds
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0030111 regulation of Wnt signaling pathway
GO:0030223 neutrophil differentiation
GO:0030307 positive regulation of cell growth
GO:0030326 embryonic limb morphogenesis
GO:0030335 positive regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030854 positive regulation of granulocyte differentiation
GO:0030879 mammary gland development
GO:0032696 negative regulation of interleukin-13 production
GO:0032713 negative regulation of interleukin-4 production
GO:0032714 negative regulation of interleukin-5 production
GO:0033153 T cell receptor V(D)J recombination
GO:0042100 B cell proliferation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043401 steroid hormone mediated signaling pathway
GO:0043586 tongue development
GO:0043923 positive regulation by host of viral transcription
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045063 T-helper 1 cell differentiation
GO:0045843 negative regulation of striated muscle tissue development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046632 alpha-beta T cell differentiation
GO:0048069 eye pigmentation
GO:0048341 paraxial mesoderm formation
GO:0048468 cell development
GO:0048747 muscle fiber development
GO:0050909 sensory perception of taste
GO:0060021 palate development
GO:0060033 anatomical structure regression
GO:0060070 canonical Wnt signaling pathway
GO:0060325 face morphogenesis
GO:0060326 cell chemotaxis
GO:0060561 apoptotic process involved in morphogenesis
GO:0060710 chorio-allantoic fusion
GO:0061153 trachea gland development
GO:0071345 cellular response to cytokine stimulus
GO:0071353 cellular response to interleukin-4
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0071866 negative regulation of apoptotic process in bone marrow
GO:0071895 odontoblast differentiation
GO:0071899 negative regulation of estrogen receptor binding
GO:0090068 positive regulation of cell cycle process
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1902262 apoptotic process involved in patterning of blood vessels
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0032993 protein-DNA complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Notch pathway
TGF_beta_Receptor pathway
Wnt pathway
REACTOME
truncated APC mutants destabilize the destruction complex pathway
binding of TCF/LEF:CTNNB1 to target gene promoters pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
AMER1 mutants destabilize the destruction complex pathway
Ca2+ pathway pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
beta-catenin independent WNT signaling pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by Wnt pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of beta-catenin by the destruction complex pathway
deactivation of the beta-catenin transactivating complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Signal Transduction pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
repression of WNT target genes pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
formation of the beta-catenin:TCF transactivating complex pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Adherens junction pathway
Melanogenesis pathway
Pathways in cancer pathway
Colorectal cancer pathway
Endometrial cancer pathway
Prostate cancer pathway
Thyroid cancer pathway
Basal cell carcinoma pathway
Acute myeloid leukemia pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
INOH
Wnt signaling pathway pathway
PID BIOCARTA
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
PID NCI
Regulation of nuclear beta catenin signaling and target gene transcription
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.743478
RefSeq NM_001130713 NM_001130714 NM_001166119 NM_016269 XM_005263048
HUGO
OMIM
CCDS CCDS3679 CCDS47122 CCDS47123 CCDS54791
HPRD 01075
IMGT
EMBL
GenPept
RNA Seq Atlas