Homo sapiens Gene: TAF2
Summary
InnateDB Gene IDBG-33912.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAF2
Gene Name TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
Synonyms CIF150; MRT40; TAF2B; TAFII150;
Species Homo sapiens
Ensembl Gene ENSG00000064313
Encoded Proteins
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:119730775-119832863
Strand Reverse strand
Band q24.12
Transcripts
ENST00000378164 ENSP00000367406
ENST00000519355
ENST00000523078
ENST00000523098 ENSP00000428690
ENST00000523904 ENSP00000430832
ENST00000523734
ENST00000521007 ENSP00000428484
ENST00000529653 ENSP00000436750
ENST00000526969
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 25 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006508 proteolysis
GO:0014070 response to organic cyclic compound
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005669 transcription factor TFIID complex
GO:0033276 transcription factor TFTC complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
RNA Polymerase II Transcription Initiation pathway
Late Phase of HIV Life Cycle pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
RNA Polymerase II Transcription pathway
RNA Polymerase II HIV Promoter Escape pathway
RNA Polymerase II Promoter Escape pathway
HIV Life Cycle pathway
RNA Polymerase II Pre-transcription Events pathway
Transcription of the HIV genome pathway
HIV Infection pathway
HIV Transcription Initiation pathway
Gene Expression pathway
Disease pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
KEGG
Basal transcription factors pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H0YEX2
UniProt Splice Variant
Entrez Gene 6873
UniGene Hs.122752 Hs.604707
RefSeq NM_003184
HUGO HGNC:11536
OMIM 604912
CCDS CCDS34937
HPRD 07060
IMGT
EMBL AC021945 AC107960
GenPept
RNA Seq Atlas 6873