InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAF2

Summary

InnateDB Gene

IDBG-33912.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF2

Gene Name

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa

Synonyms

CIF150; MRT40; TAF2B; TAFII150

Species

Homo sapiens

Ensembl Gene

ENSG00000064313

Encoded Proteins

IDBP-33914

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa

IDBP-476171

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa

IDBP-480646

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa

IDBP-476699

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa

IDBP-590545

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:119730775-119832863

Strand

Reverse strand

Band

q24.12

Transcripts

ENST00000378164	ENSP00000367406
ENST00000519355
ENST00000523078
ENST00000523098	ENSP00000428690
ENST00000523904	ENSP00000430832
ENST00000523734
ENST00000521007	ENSP00000428484
ENST00000529653	ENSP00000436750
ENST00000526969

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	25 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006508	proteolysis
GO:0014070	response to organic cyclic compound
GO:0045944	positive regulation of transcription from RNA polymerase II promoter