InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ELOVL6

Summary

InnateDB Gene

IDBG-34174.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELOVL6

Gene Name

ELOVL fatty acid elongase 6

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000170522

Encoded Proteins

IDBP-34176

ELOVL fatty acid elongase 6

IDBP-241240

ELOVL fatty acid elongase 6

IDBP-484224

ELOVL fatty acid elongase 6

IDBP-475665

ELOVL fatty acid elongase 6

IDBP-477952

ELOVL fatty acid elongase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:110045846-110199199

Strand

Reverse strand

Band

q25

Transcripts

ENST00000302274	ENSP00000304736
ENST00000394607	ENSP00000378105
ENST00000514184	ENSP00000424023
ENST00000507451
ENST00000506625	ENSP00000425488
ENST00000506461
ENST00000503885	ENSP00000426086
ENST00000513003

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

Biological Process

GO:0006633	fatty acid biosynthetic process
GO:0019367	fatty acid elongation, saturated fatty acid
GO:0019432	triglyceride biosynthetic process
GO:0030497	fatty acid elongation
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0042759	long-chain fatty acid biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000041220

View Gene Order

ENSBTAG00000010564

Not yet available

Pathways

NETPATH

REACTOME

REACT_147904

Activation of gene expression by SREBF (SREBP) pathway

REACT_147797

Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway

REACT_380

Synthesis of very long-chain fatty acyl-CoAs pathway

REACT_1319

Fatty Acyl-CoA Biosynthesis pathway

REACT_1190

Triglyceride Biosynthesis pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa01040

Biosynthesis of unsaturated fatty acids pathway

hsa00062

Fatty acid elongation pathway

INOH

PID NCI

Cross-References

SwissProt

Q9H5J4

TrEMBL

A0A024RDK5 D6RCU0 D6RHI2

UniProt Splice Variant

Entrez Gene

79071

UniGene

Hs.17519 Hs.412939 Hs.652828

RefSeq

NM_001130721 NM_024090

HUGO

HGNC:15829

OMIM

611546

CCDS

CCDS3690

HPRD

13269

IMGT

EMBL

AC004050 AC093770 AK027031 AK074813 BC001305 CH471057

GenPept

AAH01305 AAY40928 BAB15632 BAC11225 EAX06259 EAX06260

RNA Seq Atlas

79071