Version 5.4
Homo sapiens Gene: MLL5
Summary
InnateDB Gene IDBG-34737.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLL5
Gene Name myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000005483
Encoded Proteins
IDBP-34739
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
IDBP-34745
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
IDBP-34747
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
IDBP-34749
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
IDBP-34751
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
IDBP-481639
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
IDBP-478306
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
IDBP-474729
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
IDBP-476350
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
IDBP-481923
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
IDBP-810212
lysine (K)-specific methyltransferase 2E
IDBP-477982
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
IDBP-477054
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
IDBP-810232
lysine (K)-specific methyltransferase 2E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:105014179-105114361
Strand Forward strand
Band q22.3
Transcripts
ENST00000311117 ENSP00000312379
ENST00000334884 ENSP00000335398
ENST00000257745 ENSP00000257745
ENST00000334914 ENSP00000333986
ENST00000334877 ENSP00000335599
ENST00000478990 ENSP00000419883
ENST00000480368
ENST00000495267 ENSP00000420415
ENST00000476671 ENSP00000417888
ENST00000474203 ENSP00000420206
ENST00000482560 ENSP00000417193
ENST00000485619
ENST00000468607
ENST00000496191
ENST00000479838 ENSP00000473963
ENST00000478079 ENSP00000419525
ENST00000473063 ENSP00000417156
ENST00000622386 ENSP00000482147
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
Biological Process
GO:0002446 neutrophil mediated immunity
GO:0006306 DNA methylation
GO:0006351 transcription, DNA-templated
GO:0007050 cell cycle arrest
GO:0030218 erythrocyte differentiation
GO:0030854 positive regulation of granulocyte differentiation
GO:0042119 neutrophil activation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048384 retinoic acid receptor signaling pathway
GO:0051568 histone H3-K4 methylation
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016607 nuclear speck
GO:0070688 MLL5-L complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029004
View Gene Order
ENSBTAG00000009207
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592262 Hs.613024
RefSeq NM_018682 NM_182931 XM_005250493
HUGO
OMIM
CCDS CCDS34723
HPRD 10528
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca