Version 5.4
Bos taurus Gene: MLL5
Summary
InnateDB Gene IDBG-631821.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLL5
Gene Name histone-lysine N-methyltransferase MLL5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009207
Encoded Proteins
IDBP-683387
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005483:
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:46474531-46565717
Strand Forward strand
Band
Transcripts
ENSBTAT00000012129 ENSBTAP00000012129
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0046872 metal ion binding
Biological Process
GO:0002446 neutrophil mediated immunity
GO:0006306 DNA methylation
GO:0030218 erythrocyte differentiation
GO:0030854 positive regulation of granulocyte differentiation
GO:0042119 neutrophil activation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048384 retinoic acid receptor signaling pathway
GO:0051568 histone H3-K4 methylation
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0070688 MLL5-L complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000005483
View Gene Order
ENSMUSG00000029004
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
mmu00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MFD2
UniProt Splice Variant
Entrez Gene 539121
UniGene Bt.35488
RefSeq NM_001082451 XM_005205362 XM_005205363 XM_005205364 XM_005205365 XM_005205367
HUGO HGNC:18541
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02010537
GenPept
RNA Seq Atlas 539121

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca