Version 5.4
Homo sapiens Gene: PCK2
Summary
InnateDB Gene IDBG-3497.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCK2
Gene Name phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Synonyms PEPCK; PEPCK-M; PEPCK2
Species Homo sapiens
Ensembl Gene ENSG00000100889
Encoded Proteins
IDBP-3499
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
IDBP-236345
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
IDBP-583139
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
IDBP-592190
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
IDBP-585496
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
IDBP-594950
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
IDBP-604010
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
IDBP-587900
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
IDBP-595558
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
IDBP-597874
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
IDBP-594132
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
IDBP-601368
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:24094053-24110598
Strand Forward strand
Band q11.2
Transcripts
ENST00000216780 ENSP00000216780
ENST00000396973 ENSP00000380171
ENST00000559250 ENSP00000453444
ENST00000560736 ENSP00000453998
ENST00000559837 ENSP00000453751
ENST00000560106 ENSP00000454020
ENST00000545054 ENSP00000441826
ENST00000561050
ENST00000561286 ENSP00000454011
ENST00000558674
ENST00000560657
ENST00000559584 ENSP00000452748
ENST00000558096 ENSP00000453656
ENST00000559503 ENSP00000453528
ENST00000559171 ENSP00000453791
ENST00000557969
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004611 phosphoenolpyruvate carboxykinase activity
GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016301 kinase activity
GO:0017076 purine nucleotide binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006090 pyruvate metabolic process
GO:0006094 gluconeogenesis
GO:0006107 oxaloacetate metabolic process
GO:0006116 NADH oxidation
GO:0016310 phosphorylation
GO:0032024 positive regulation of insulin secretion
GO:0044281 small molecule metabolic process
GO:0051384 response to glucocorticoid
GO:0071333 cellular response to glucose stimulus
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040618
View Gene Order
ENSBTAG00000011934
Not yet available
Pathways
NETPATH
REACTOME
REACT_1520
Gluconeogenesis pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00020
Citrate cycle (TCA cycle) pathway
hsa04910
Insulin signaling pathway pathway
hsa03320
PPAR signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
INOH
INOH website
Citrate cycle pathway
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.75812
RefSeq NM_001018073 NM_001291556 NM_004563
HUGO
OMIM
CCDS CCDS41928 CCDS9609
HPRD 02026
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca