Homo sapiens Gene: PCK2
Summary
InnateDB Gene IDBG-3497.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCK2
Gene Name phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Synonyms PEPCK; PEPCK-M; PEPCK2;
Species Homo sapiens
Ensembl Gene ENSG00000100889
Encoded Proteins
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:24094053-24110598
Strand Forward strand
Band q11.2
Transcripts
ENST00000216780 ENSP00000216780
ENST00000396973 ENSP00000380171
ENST00000559250 ENSP00000453444
ENST00000560736 ENSP00000453998
ENST00000559837 ENSP00000453751
ENST00000560106 ENSP00000454020
ENST00000545054 ENSP00000441826
ENST00000561050
ENST00000561286 ENSP00000454011
ENST00000558674
ENST00000560657
ENST00000559584 ENSP00000452748
ENST00000558096 ENSP00000453656
ENST00000559503 ENSP00000453528
ENST00000559171 ENSP00000453791
ENST00000557969
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004611 phosphoenolpyruvate carboxykinase activity
GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016301 kinase activity
GO:0017076 purine nucleotide binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006090 pyruvate metabolic process
GO:0006094 gluconeogenesis
GO:0006107 oxaloacetate metabolic process
GO:0006116 NADH oxidation
GO:0016310 phosphorylation
GO:0032024 positive regulation of insulin secretion
GO:0044281 small molecule metabolic process
GO:0051384 response to glucocorticoid
GO:0071333 cellular response to glucose stimulus
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Gluconeogenesis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Citrate cycle (TCA cycle) pathway
Pyruvate metabolism pathway
PPAR signaling pathway pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Proximal tubule bicarbonate reclamation pathway
INOH
Citrate cycle pathway
PID BIOCARTA
PID NCI
Glucocorticoid receptor regulatory network
Cross-References
SwissProt Q16822
TrEMBL H0YMU6 H0YNG4
UniProt Splice Variant
Entrez Gene 5106
UniGene Hs.75812
RefSeq NM_001018073 NM_004563 NM_001291556
HUGO HGNC:8725
OMIM 614095
CCDS CCDS41928 CCDS9609
HPRD 02026
IMGT
EMBL AL136295 BC001454 BX248272 X92720 Y11484
GenPept AAH01454 CAA63380 CAA72272 CAD62600
RNA Seq Atlas 5106