Version 5.4
Bos taurus Gene: PRSS12
Summary
InnateDB Gene IDBG-639949.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRSS12
Gene Name neurotrypsin precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020705
Encoded Proteins
IDBP-692166
protease, serine, 12 (neurotrypsin, motopsin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164099:
This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1). [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:7944016-8020932
Strand Forward strand
Band
Transcripts
ENSBTAT00000027594 ENSBTAP00000027594
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005044 scavenger receptor activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0006887 exocytosis
GO:0006898 receptor-mediated endocytosis
GO:0031638 zymogen activation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0031410 cytoplasmic vesicle
GO:0043083 synaptic cleft
GO:0043195 terminal bouton
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000164099
View Gene Order
ENSMUSG00000027978
View Gene Order
Cross-References
SwissProt
TrEMBL E1BK01
UniProt Splice Variant
Entrez Gene 512034
UniGene Bt.33176
RefSeq NM_001193222
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02016331 DAAA02016332 DAAA02016333 DAAA02016334 DAAA02016335
GenPept
RNA Seq Atlas 512034

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca