Homo sapiens Gene: FABP2
Summary
InnateDB Gene IDBG-35741.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FABP2
Gene Name fatty acid binding protein 2, intestinal
Synonyms FABPI; I-FABP
Species Homo sapiens
Ensembl Gene ENSG00000145384
Encoded Proteins
fatty acid binding protein 2, intestinal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:119317250-119322390
Strand Reverse strand
Band q26
Transcripts
ENST00000274024 ENSP00000274024
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005504 fatty acid binding
Biological Process
GO:0006810 transport
GO:0007586 digestion
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
PPAR signaling pathway pathway
Fat digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt P12104
TrEMBL
UniProt Splice Variant
Entrez Gene 2169
UniGene Hs.282265
RefSeq NM_000134
HUGO HGNC:3556
OMIM 134640
CCDS CCDS3712
HPRD
IMGT
EMBL AC092656 BC069466 BC069617 BC069625 BC069637 BC111791 M18079
GenPept AAA52417 AAH69466 AAH69617 AAH69625 AAH69637 AAI11792
RNA Seq Atlas 2169