Version 5.4
Homo sapiens Gene: SEMA3F
Summary
InnateDB Gene IDBG-35942.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA3F
Gene Name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Synonyms SEMA-IV; SEMA4; SEMAK
Species Homo sapiens
Ensembl Gene ENSG00000001617
Encoded Proteins
IDBP-35946
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
IDBP-377935
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
IDBP-377940
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
IDBP-377943
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
IDBP-377947
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
IDBP-377952
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
IDBP-377956
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 [PubMed 8269517]). Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993 [PubMed 8402908]) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995 [PubMed 7637782]), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:50155045-50189075
Strand Forward strand
Band p21.31
Transcripts
ENST00000002829 ENSP00000002829
ENST00000414301 ENSP00000392588
ENST00000450338 ENSP00000398399
ENST00000413852 ENSP00000388931
ENST00000426511 ENSP00000400549
ENST00000434342 ENSP00000409859
ENST00000420831 ENSP00000416356
ENST00000493743
ENST00000470737
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0045499 chemorepellent activity
Biological Process
GO:0001755 neural crest cell migration
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0021612 facial nerve structural organization
GO:0021637 trigeminal nerve structural organization
GO:0021675 nerve development
GO:0021785 branchiomotor neuron axon guidance
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0048846 axon extension involved in axon guidance
GO:0050919 negative chemotaxis
GO:0061549 sympathetic ganglion development
GO:0097490 sympathetic neuron projection extension
GO:0097491 sympathetic neuron projection guidance
GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034684
View Gene Order
ENSBTAG00000018307
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H7C4A2
UniProt Splice Variant
Entrez Gene 6405
UniGene Hs.32981 Hs.734969
RefSeq NM_004186 XM_005265381 XM_005265382 XM_006713290
HUGO HGNC:10728
OMIM 601124
CCDS CCDS2811
HPRD 03079
IMGT
EMBL AC000063 AC104450
GenPept
RNA Seq Atlas 6405

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca