Homo sapiens Gene: NUDT12
Summary
InnateDB Gene IDBG-36029.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUDT12
Gene Name nudix (nucleoside diphosphate linked moiety X)-type motif 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112874
Encoded Proteins
nudix (nucleoside diphosphate linked moiety X)-type motif 12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:103548855-103562793
Strand Reverse strand
Band q21.2
Transcripts
ENST00000230792 ENSP00000230792
ENST00000507423 ENSP00000424521
ENST00000515407
ENST00000508889
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000210 NAD+ diphosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0035529 NADH pyrophosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006742 NADP catabolic process
GO:0008152 metabolic process
GO:0019677 NAD catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005777 peroxisome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Nicotinate and nicotinamide metabolism pathway
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E7EM93
UniProt Splice Variant
Entrez Gene 83594
UniGene Hs.434289
RefSeq NM_001300741 XM_005272096 XM_005272097 NM_031438 XM_005272095
HUGO HGNC:18826
OMIM 609232
CCDS CCDS75284 CCDS4096
HPRD 10123
IMGT
EMBL AC008519
GenPept
RNA Seq Atlas 83594