Homo sapiens Gene: IL21
Summary
InnateDB Gene IDBG-36977.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL21
Gene Name interleukin 21
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138684
Encoded Proteins
interleukin 21
interleukin 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL21 is a cytokine that has broad effects on both innate and adaptive immune responses.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] IL21 induces apoptosis of conventional dendritic cells.
Entrez Gene
Summary This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:122612628-122621069
Strand Reverse strand
Band q27
Transcripts
ENST00000264497 ENSP00000264497
ENST00000611104 ENSP00000477555
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 6 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005134 interleukin-2 receptor binding
Biological Process
GO:0002729 positive regulation of natural killer cell cytokine production
GO:0006955 immune response
GO:0007165 signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0030890 positive regulation of B cell proliferation
GO:0032733 positive regulation of interleukin-10 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032825 positive regulation of natural killer cell differentiation
GO:0034105 positive regulation of tissue remodeling
GO:0042102 positive regulation of T cell proliferation
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045078 positive regulation of interferon-gamma biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0048469 cell maturation
GO:0050729 positive regulation of inflammatory response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001207006 NM_021803
HUGO
OMIM
CCDS CCDS3727 CCDS75189
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas