|Homo sapiens Gene: IL21|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||interleukin 21|
|Useful resources||Stemformatics EHFPI ImmGen|
IL21 is a cytokine that has broad effects on both innate and adaptive immune responses.
|InnateDB Annotation from Orthologs|
[Mus musculus] IL21 induces apoptosis of conventional dendritic cells.
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
|Genomic Location||Chromosome 4:122612628-122621069|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
|UniProt Splice Variant|
|RNA Seq Atlas|