Version 5.4
Homo sapiens Gene: RBCK1
Summary
InnateDB Gene IDBG-37270.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBCK1
Gene Name RanBP-type and C3HC4-type zinc finger containing 1
Synonyms C20orf18; HOIL-1; HOIL1; PBMEI; RBCK2; RNF54; UBCE7IP3; XAP3; XAP4; ZRANB4
Species Homo sapiens
Ensembl Gene ENSG00000125826
Encoded Proteins
IDBP-37272
RanBP-type and C3HC4-type zinc finger containing 1
IDBP-37274
RanBP-type and C3HC4-type zinc finger containing 1
IDBP-37280
RanBP-type and C3HC4-type zinc finger containing 1
IDBP-37282
RanBP-type and C3HC4-type zinc finger containing 1
IDBP-228710
RanBP-type and C3HC4-type zinc finger containing 1
IDBP-361785
RanBP-type and C3HC4-type zinc finger containing 1
IDBP-361816
RanBP-type and C3HC4-type zinc finger containing 1
IDBP-361839
RanBP-type and C3HC4-type zinc finger containing 1
IDBP-361847
RanBP-type and C3HC4-type zinc finger containing 1
IDBP-482192
RanBP-type and C3HC4-type zinc finger containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19136968
RBCK1 (LUBAC) complexes with RNF31 and is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of IKBKG.
Entrez Gene
Summary The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:407498-430966
Strand Forward strand
Band p13
Transcripts
ENST00000382214 ENSP00000371649
ENST00000382181 ENSP00000371616
ENST00000356286 ENSP00000348632
ENST00000353660 ENSP00000254960
ENST00000400247 ENSP00000383106
ENST00000400245
ENST00000411647 ENSP00000415080
ENST00000415942 ENSP00000405288
ENST00000441733 ENSP00000387799
ENST00000414880 ENSP00000393841
ENST00000465226
ENST00000475269 ENSP00000417173
ENST00000468272
ENST00000621487
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 107 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 107 [view]
Protein-Protein 107 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0043130 ubiquitin binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0016032 viral process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060546 negative regulation of necroptotic process
GO:0097039 protein linear polyubiquitination
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0071797 LUBAC complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027466
View Gene Order
ENSBTAG00000017002
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.247280 Hs.705866 Hs.732926
RefSeq NM_006462 NM_031229
HUGO
OMIM
CCDS CCDS12998 CCDS13000
HPRD 16643
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca