Version 5.4
Homo sapiens Gene: MCC
Summary
InnateDB Gene IDBG-37345.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCC
Gene Name mutated in colorectal cancers
Synonyms MCC1
Species Homo sapiens
Ensembl Gene ENSG00000171444
Encoded Proteins
IDBP-37349
mutated in colorectal cancers
IDBP-293445
mutated in colorectal cancers
IDBP-482452
mutated in colorectal cancers
IDBP-807548
mutated in colorectal cancers
IDBP-807543
mutated in colorectal cancers
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:113022099-113488830
Strand Reverse strand
Band q22.2
Transcripts
ENST00000302475 ENSP00000305617
ENST00000408903 ENSP00000386227
ENST00000515367 ENSP00000421615
ENST00000514701 ENSP00000485220
ENST00000502648
ENST00000505604
ENST00000511847
ENST00000506605
ENST00000511242
ENST00000624689 ENSP00000485492
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
Experimentally validated
Total 52 [view]
Protein-Protein 52 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004872 receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0010633 negative regulation of epithelial cell migration
GO:0016055 Wnt signaling pathway
GO:0050680 negative regulation of epithelial cell proliferation
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0030027 lamellipodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000071856
View Gene Order
ENSBTAG00000035858
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.593171
RefSeq NM_001085377 NM_002387
HUGO
OMIM
CCDS CCDS4111 CCDS43351
HPRD 01157
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca