Version 5.4
Homo sapiens Gene: BORA
Summary
InnateDB Gene IDBG-37374.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BORA
Gene Name bora, aurora kinase A activator
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136122
Encoded Proteins
IDBP-37376
bora, aurora kinase A activator
IDBP-37378
bora, aurora kinase A activator
IDBP-37380
bora, aurora kinase A activator
IDBP-812990
bora, aurora kinase A activator
IDBP-812999
bora, aurora kinase A activator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:72727749-72756198
Strand Forward strand
Band q21.33
Transcripts
ENST00000377815 ENSP00000367046
ENST00000377814 ENSP00000367045
ENST00000390667 ENSP00000375082
ENST00000471712
ENST00000464754
ENST00000618209 ENSP00000479349
ENST00000613797 ENSP00000479266
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0007067 mitotic nuclear division
GO:0007088 regulation of mitosis
GO:0032880 regulation of protein localization
GO:0060236 regulation of mitotic spindle organization
Cellular Component
GO:0005829 cytosol
GO:0072687 meiotic spindle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022070
View Gene Order
ENSBTAG00000019886
Not yet available
Pathways
NETPATH
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_115566
Cell Cycle pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL B4DQ30
UniProt Splice Variant
Entrez Gene 79866
UniGene Hs.735605 Hs.743339
RefSeq NM_001286747 NM_001286746 NM_024808
HUGO HGNC:24724
OMIM 610510
CCDS CCDS66560 CCDS73583 CCDS9446
HPRD 13389
IMGT
EMBL AK298608 AL138695 CH471093
GenPept BAG60792 EAW80515
RNA Seq Atlas 79866

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca