InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FECH

Summary

InnateDB Gene

IDBG-3741.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FECH

Gene Name

ferrochelatase

Synonyms

EPP; FCE

Species

Homo sapiens

Ensembl Gene

ENSG00000066926

Encoded Proteins

IDBP-3743

ferrochelatase

IDBP-3745

ferrochelatase

IDBP-727312

IDBP-727276

IDBP-727973

IDBP-726861

IDBP-725914

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:57548283-57586772

Strand

Reverse strand

Band

q21.31

Transcripts

ENST00000382873	ENSP00000372326
ENST00000262093	ENSP00000262093
ENST00000585747	ENSP00000465717
ENST00000592699	ENSP00000466263
ENST00000591977	ENSP00000465363
ENST00000585494	ENSP00000465243
ENST00000585699
ENST00000585878
ENST00000591215	ENSP00000467461
ENST00000592111

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004325	ferrochelatase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008198	ferrous iron binding
GO:0020037	heme binding
GO:0030350	iron-responsive element binding
GO:0046906	tetrapyrrole binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006778	porphyrin-containing compound metabolic process
GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006783	heme biosynthetic process
GO:0008203	cholesterol metabolic process
GO:0009416	response to light stimulus
GO:0009589	detection of UV
GO:0010038	response to metal ion
GO:0010288	response to lead ion
GO:0010468	regulation of gene expression
GO:0010999	regulation of eIF2 alpha phosphorylation by heme
GO:0017085	response to insecticide
GO:0030218	erythrocyte differentiation
GO:0034379	very-low-density lipoprotein particle assembly
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0046501	protoporphyrinogen IX metabolic process
GO:0046685	response to arsenic-containing substance
GO:0046984	regulation of hemoglobin biosynthetic process
GO:0051597	response to methylmercury
GO:0055072	iron ion homeostasis
GO:0070541	response to platinum ion
GO:0071549	cellular response to dexamethasone stimulus

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024588

View Gene Order

ENSBTAG00000006393

Not yet available

Pathways

NETPATH

REACTOME

REACT_9465

Heme biosynthesis pathway

REACT_9431

Metabolism of porphyrins pathway

REACT_111217

Metabolism pathway

KEGG

hsa00860

Porphyrin and chlorophyll metabolism pathway

INOH

INOH website

Porphyrin metabolism pathway

PID NCI

hif1_tfpathway

HIF-1-alpha transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.365365 Hs.613777 Hs.710934

RefSeq

NM_000140 NM_001012515

HUGO

OMIM

CCDS

CCDS11964 CCDS32836

HPRD

01509

IMGT

EMBL

GenPept

RNA Seq Atlas