Homo sapiens Gene: FECH
Summary
InnateDB Gene IDBG-3741.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FECH
Gene Name ferrochelatase
Synonyms EPP; FCE;
Species Homo sapiens
Ensembl Gene ENSG00000066926
Encoded Proteins
ferrochelatase
ferrochelatase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:57548283-57586772
Strand Reverse strand
Band q21.31
Transcripts
ENST00000382873 ENSP00000372326
ENST00000262093 ENSP00000262093
ENST00000585747 ENSP00000465717
ENST00000592699 ENSP00000466263
ENST00000591977 ENSP00000465363
ENST00000585494 ENSP00000465243
ENST00000585699
ENST00000585878
ENST00000591215 ENSP00000467461
ENST00000592111
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004325 ferrochelatase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0020037 heme binding
GO:0030350 iron-responsive element binding
GO:0046906 tetrapyrrole binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006778 porphyrin-containing compound metabolic process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006783 heme biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0009416 response to light stimulus
GO:0009589 detection of UV
GO:0010038 response to metal ion
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010999 regulation of eIF2 alpha phosphorylation by heme
GO:0017085 response to insecticide
GO:0030218 erythrocyte differentiation
GO:0034379 very-low-density lipoprotein particle assembly
GO:0042493 response to drug
GO:0044281 small molecule metabolic process
GO:0045471 response to ethanol
GO:0046501 protoporphyrinogen IX metabolic process
GO:0046685 response to arsenic-containing substance
GO:0046984 regulation of hemoglobin biosynthetic process
GO:0051597 response to methylmercury
GO:0055072 iron ion homeostasis
GO:0070541 response to platinum ion
GO:0071549 cellular response to dexamethasone stimulus
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Heme biosynthesis pathway
Metabolism of porphyrins pathway
Metabolism pathway
KEGG
Porphyrin and chlorophyll metabolism pathway
INOH
Porphyrin metabolism pathway
PID BIOCARTA
Hemoglobins chaperone [Biocarta view]
PID NCI
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.365365 Hs.613777 Hs.710934
RefSeq NM_000140 NM_001012515
HUGO
OMIM
CCDS CCDS11964 CCDS32836
HPRD 01509
IMGT
EMBL
GenPept
RNA Seq Atlas