InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FECH

Summary

InnateDB Gene

IDBG-644814.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FECH

Gene Name

Ferrochelatase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006393

Encoded Proteins

IDBP-697481

Ferrochelatase, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066926:
The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 24:57298434-57333273

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008384

ENSBTAP00000008384

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004325	ferrochelatase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016829	lyase activity
GO:0020037	heme binding
GO:0030350	iron-responsive element binding
GO:0046872	metal ion binding
GO:0046906	tetrapyrrole binding
GO:0051536	iron-sulfur cluster binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006783	heme biosynthetic process
GO:0008203	cholesterol metabolic process
GO:0009416	response to light stimulus
GO:0009589	detection of UV
GO:0010468	regulation of gene expression
GO:0010999	regulation of eIF2 alpha phosphorylation by heme
GO:0030218	erythrocyte differentiation
GO:0034379	very-low-density lipoprotein particle assembly
GO:0046501	protoporphyrinogen IX metabolic process
GO:0046984	regulation of hemoglobin biosynthetic process
GO:0055072	iron ion homeostasis