Bos taurus Gene: FECH
Summary
InnateDB Gene IDBG-644814.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FECH
Gene Name Ferrochelatase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006393
Encoded Proteins
Ferrochelatase, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066926:
The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 24:57298434-57333273
Strand Reverse strand
Band
Transcripts
ENSBTAT00000008384 ENSBTAP00000008384
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004325 ferrochelatase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0020037 heme binding
GO:0030350 iron-responsive element binding
GO:0046872 metal ion binding
GO:0046906 tetrapyrrole binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006783 heme biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0009416 response to light stimulus
GO:0009589 detection of UV
GO:0010468 regulation of gene expression
GO:0010999 regulation of eIF2 alpha phosphorylation by heme
GO:0030218 erythrocyte differentiation
GO:0034379 very-low-density lipoprotein particle assembly
GO:0046501 protoporphyrinogen IX metabolic process
GO:0046984 regulation of hemoglobin biosynthetic process
GO:0055072 iron ion homeostasis
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Metabolism of porphyrins pathway
Heme biosynthesis pathway
Metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Heme biosynthesis pathway
Metabolism of porphyrins pathway
Metabolism pathway
Metabolism pathway
Heme biosynthesis pathway
Metabolism of porphyrins pathway
KEGG
Porphyrin and chlorophyll metabolism pathway
Porphyrin and chlorophyll metabolism pathway
INOH
Porphyrin metabolism pathway
PID BIOCARTA
Hemoglobins chaperone [Biocarta view]
PID NCI
HIF-1-alpha transcription factor network
Cross-References
SwissProt P22600
TrEMBL
UniProt Splice Variant
Entrez Gene 281158
UniGene Bt.88608
RefSeq NM_174054
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL L34173
GenPept AAA79169
RNA Seq Atlas 281158
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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