Version 5.4
Homo sapiens Gene: NEK8
Summary
InnateDB Gene IDBG-37575.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEK8
Gene Name NIMA-related kinase 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000160602
Encoded Proteins
IDBP-37577
NIMA (never in mitosis gene a)- related kinase 8
IDBP-762390
IDBP-762531
IDBP-763951
IDBP-764239
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:28725897-28743455
Strand Forward strand
Band q11.2
Transcripts
ENST00000268766 ENSP00000268766
ENST00000543014 ENSP00000465859
ENST00000592510 ENSP00000466476
ENST00000579671 ENSP00000467335
ENST00000593261
ENST00000584342
ENST00000579060 ENSP00000466896
ENST00000581000
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0009887 organ morphogenesis
GO:0035330 regulation of hippo signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0072372 primary cilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017405
View Gene Order
ENSBTAG00000015535
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.448468 Hs.574403
RefSeq NM_178170
HUGO
OMIM
CCDS CCDS32597
HPRD 14822
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca