Homo sapiens Gene: PIK3R2
InnateDB Gene IDBG-37719.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIK3R2
Gene Name phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Species Homo sapiens
Ensembl Gene ENSG00000105647
Encoded Proteins
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:18153118-18170540
Strand Forward strand
Band p13.11
ENST00000222254 ENSP00000222254
ENST00000426902 ENSP00000395636
ENST00000464016 ENSP00000476825
ENST00000617130 ENSP00000477864
ENST00000617642 ENSP00000484714
Number of Interactions This gene and/or its encoded proteins are associated with 122 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 122 [view]
Protein-Protein 122 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0030971 receptor tyrosine kinase binding
GO:0035014 phosphatidylinositol 3-kinase regulator activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007596 blood coagulation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Alpha6Beta4Integrin pathway
AndrogenReceptor pathway
Notch pathway
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
RANKL pathway
Leptin pathway
TSH pathway
Prolactin pathway
IL11 pathway
Signaling by FGFR in disease pathway
G alpha (12/13) signalling events pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
Metabolism of lipids and lipoproteins pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Cell-Cell communication pathway
TCR signaling pathway
PI-3K cascade pathway
Synthesis of PIPs at the plasma membrane pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by Rho GTPases pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Nephrin interactions pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Cytokine Signaling in Immune system pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Platelet activation, signaling and aggregation pathway
Signaling by SCF-KIT pathway
G-protein beta:gamma signalling pathway
Role of phospholipids in phagocytosis pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
CD28 co-stimulation pathway
Tie2 Signaling pathway
PI3K Cascade pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
Insulin receptor signalling cascade pathway
GPVI-mediated activation cascade pathway
Rho GTPase cycle pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
PI Metabolism pathway
Downstream TCR signaling pathway
Phospholipid metabolism pathway
IRS-related events pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
Interleukin-7 signaling pathway
Signaling by FGFR pathway
CD28 dependent PI3K/Akt signaling pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
Metabolism pathway
Costimulation by the CD28 family pathway
G beta:gamma signalling through PI3Kgamma pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Cell surface interactions at the vascular wall pathway
Disease pathway
Hemostasis pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
Regulation of signaling by CBL pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Phosphatidylinositol signaling system pathway
mTOR signaling pathway pathway
Apoptosis pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Leukocyte transendothelial migration pathway
Neurotrophin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Type II diabetes mellitus pathway
Aldosterone-regulated sodium reabsorption pathway
Carbohydrate digestion and absorption pathway
Bacterial invasion of epithelial cells pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Amoebiasis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
IGF1 signaling pathway pathway
PDGF signaling pathway pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
UniProt Splice Variant
Entrez Gene 5296
RefSeq NM_005027
OMIM 603157
RNA Seq Atlas 5296