Version 5.4
Homo sapiens Gene: CHTF8
Summary
InnateDB Gene IDBG-38862.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHTF8
Gene Name CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168802
Encoded Proteins
IDBP-38864
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
IDBP-233582
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
IDBP-379692
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
IDBP-474090
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
IDBP-483281
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
IDBP-747880
IDBP-474381
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
IDBP-477255
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
IDBP-484175
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
IDBP-748269
IDBP-753097
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair. This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors. Alternatively spliced transcript variants have been described. This gene has a pseudogene on chromosome X. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:69118010-69132584
Strand Reverse strand
Band q22.1
Transcripts
ENST00000306585 ENSP00000305687
ENST00000398235 ENSP00000381290
ENST00000448552 ENSP00000408367
ENST00000523421 ENSP00000430899
ENST00000518041 ENSP00000430079
ENST00000519534 ENSP00000462519
ENST00000519520 ENSP00000427718
ENST00000522497 ENSP00000428130
ENST00000520529 ENSP00000427728
ENST00000522091 ENSP00000455699
ENST00000567763 ENSP00000455402
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006260 DNA replication
GO:0007049 cell cycle
Cellular Component
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL J3KSJ7
UniProt Splice Variant
Entrez Gene 54921
UniGene Hs.85962
RefSeq NM_001039690 NM_001040146
HUGO HGNC:24353
OMIM 613202
CCDS CCDS42185
HPRD 16797
IMGT
EMBL AC009027
GenPept
RNA Seq Atlas 54921

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca