Homo sapiens Gene: RIPK3
Summary
InnateDB Gene IDBG-3902.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RIPK3
Gene Name receptor-interacting serine-threonine kinase 3
Synonyms RIP3;
Species Homo sapiens
Ensembl Gene ENSG00000129465
Encoded Proteins
receptor-interacting serine-threonine kinase 3
receptor-interacting serine-threonine kinase 3
receptor-interacting serine-threonine kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
RIPK3 forms a complex with TICAM1 upon Toll-like receptors (TLR) 3 and 4 activation resulting in RIPK3-dependent but TNF-independent necrosis in macrophages. (Demonstrated in mouse)
RIPK3 interacts with ZBP1 to mediate virus-induced necrosis. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Ripk3 forms a complex with Ticam1 upon Toll-like receptors (TLR) 3 and 4 activation resulting in Ripk3-dependent but TNF-independent necrosis in macrophages.
[Mus musculus] Ripk3 interacts with Zbp1 to mediate virus-induced necrosis.
[Mus musculus] Ripk3 has a novel function in NF-kB activation, dendritic cell biology, innate inflammatory-cytokine expression, and injury-induced tissue repair.
Entrez Gene
Summary The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:24336021-24340045
Strand Reverse strand
Band q12
Transcripts
ENST00000216274 ENSP00000216274
ENST00000554756 ENSP00000452328
ENST00000554569 ENSP00000451840
ENST00000557624
ENST00000557253
ENST00000554338
ENST00000557662
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004704 NF-kappaB-inducing kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0032403 protein complex binding
GO:0042802 identical protein binding
Biological Process
GO:0001914 regulation of T cell mediated cytotoxicity
GO:0002224 toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0002819 regulation of adaptive immune response
GO:0006464 cellular protein modification process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0010922 positive regulation of phosphatase activity
GO:0032147 activation of protein kinase activity
GO:0032481 positive regulation of type I interferon production
GO:0032649 regulation of interferon-gamma production
GO:0033077 T cell differentiation in thymus
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038061 NIK/NF-kappaB signaling
GO:0043029 T cell homeostasis
GO:0045087 innate immune response (InnateDB)
GO:0046006 regulation of activated T cell proliferation
GO:0046777 protein autophosphorylation
GO:0048535 lymph node development
GO:0048536 spleen development
GO:0048538 thymus development
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051260 protein homooligomerization
GO:0051291 protein heterooligomerization
GO:0051347 positive regulation of transferase activity
GO:0051351 positive regulation of ligase activity
GO:0051353 positive regulation of oxidoreductase activity
GO:0060545 positive regulation of necroptotic process
GO:0070235 regulation of activation-induced cell death of T cells
GO:0070266 necroptotic process
GO:0090312 positive regulation of protein deacetylation
GO:0097190 apoptotic signaling pathway
GO:1990000 amyloid fibril formation
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000452 regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0097342 ripoptosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
RIP-mediated NFkB activation via ZBP1 pathway
Transmembrane transport of small molecules pathway
TRIF-mediated programmed cell death pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Innate Immune System pathway
Stimuli-sensing channels pathway
IKK complex recruitment mediated by RIP1 pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
MyD88-independent cascade pathway
Ion channel transport pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
TRP channels pathway
KEGG
Cytosolic DNA-sensing pathway pathway
INOH
TNFR1 signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.268551
RefSeq NM_006871
HUGO
OMIM
CCDS CCDS9628
HPRD 09315
IMGT
EMBL
GenPept
RNA Seq Atlas