Version 5.4
Homo sapiens Gene: INPP4B
Summary
InnateDB Gene IDBG-39125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INPP4B
Gene Name inositol polyphosphate-4-phosphatase, type II, 105kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109452
Encoded Proteins
IDBP-39127
inositol polyphosphate-4-phosphatase, type II, 105kDa
IDBP-480316
inositol polyphosphate-4-phosphatase, type II, 105kDa
IDBP-480529
inositol polyphosphate-4-phosphatase, type II, 105kDa
IDBP-481980
inositol polyphosphate-4-phosphatase, type II, 105kDa
IDBP-480271
inositol polyphosphate-4-phosphatase, type II, 105kDa
IDBP-475818
inositol polyphosphate-4-phosphatase, type II, 105kDa
IDBP-479089
inositol polyphosphate-4-phosphatase, type II, 105kDa
IDBP-473607
inositol polyphosphate-4-phosphatase, type II, 105kDa
IDBP-474431
inositol polyphosphate-4-phosphatase, type II, 105kDa
IDBP-484626
inositol polyphosphate-4-phosphatase, type II, 105kDa
IDBP-480818
inositol polyphosphate-4-phosphatase, type II, 105kDa
IDBP-477749
inositol polyphosphate-4-phosphatase, type II, 105kDa
IDBP-476763
inositol polyphosphate-4-phosphatase, type II, 105kDa
IDBP-480792
inositol polyphosphate-4-phosphatase, type II, 105kDa
IDBP-474395
inositol polyphosphate-4-phosphatase, type II, 105kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:142023160-142847432
Strand Reverse strand
Band q31.21
Transcripts
ENST00000262992 ENSP00000262992
ENST00000513000 ENSP00000425487
ENST00000508116 ENSP00000423954
ENST00000509777 ENSP00000422793
ENST00000511838 ENSP00000426207
ENST00000512630 ENSP00000423771
ENST00000510812 ENSP00000427250
ENST00000514525 ENSP00000421065
ENST00000506297 ENSP00000424731
ENST00000507462 ENSP00000425764
ENST00000506217 ENSP00000424057
ENST00000506788 ENSP00000426957
ENST00000506517
ENST00000506000 ENSP00000420888
ENST00000504632
ENST00000506243
ENST00000507861 ENSP00000426897
ENST00000503927 ENSP00000422052
ENST00000514964
ENST00000505483
ENST00000512489
ENST00000508084
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO:0034593 phosphatidylinositol bisphosphate phosphatase activity
GO:0034594 phosphatidylinositol trisphosphate phosphatase activity
GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006874 cellular calcium ion homeostasis
GO:0007165 signal transduction
GO:0016311 dephosphorylation
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0045671 negative regulation of osteoclast differentiation
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046850 regulation of bone remodeling
GO:0051896 regulation of protein kinase B signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037940
View Gene Order
ENSBTAG00000014111
Not yet available
Pathways
NETPATH
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_120756
Synthesis of PIPs at the early endosome membrane pathway
REACT_150352
Synthesis of IP2, IP, and Ins in the cytosol pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL E9PHC0
UniProt Splice Variant
Entrez Gene 8821
UniGene Hs.531403 Hs.604960 Hs.732573
RefSeq NM_001101669 NM_003866 XM_005263323 XM_005263325 XM_006714401 XM_006714402
HUGO HGNC:6075
OMIM 607494
CCDS CCDS3757
HPRD 06322
IMGT
EMBL AC093860 AC093885 AC108060 AC108077 AC138657 AC139720
GenPept
RNA Seq Atlas 8821

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca