Homo sapiens Gene: EHF
Summary
InnateDB Gene IDBG-39419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EHF
Gene Name ets homologous factor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135373
Encoded Proteins
ets homologous factor
ets homologous factor
ets homologous factor
ets homologous factor
ets homologous factor
ets homologous factor
ets homologous factor
ets homologous factor
ets homologous factor
ets homologous factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:34621093-34661057
Strand Forward strand
Band p13
Transcripts
ENST00000257831 ENSP00000257831
ENST00000450654 ENSP00000399733
ENST00000527001
ENST00000530286 ENSP00000433508
ENST00000533754 ENSP00000435837
ENST00000529527 ENSP00000432905
ENST00000531728 ENSP00000436357
ENST00000525253 ENSP00000434395
ENST00000531794 ENSP00000435835
ENST00000529161
ENST00000532302 ENSP00000432460
ENST00000527935 ENSP00000436158
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 7 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
GO:0030855 epithelial cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.606452 Hs.653859
RefSeq NM_001206615 NM_001206616 NM_012153 XM_005252857 XM_005252858 XM_005252860 XM_005252862
HUGO
OMIM
CCDS CCDS55752 CCDS55753 CCDS7894
HPRD 16105
IMGT
EMBL
GenPept
RNA Seq Atlas