Version 5.4
Homo sapiens Gene: ABCE1
Summary
InnateDB Gene IDBG-39791.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCE1
Gene Name ATP-binding cassette, sub-family E (OABP), member 1
Synonyms ABC38; OABP; RLI; RNASEL1; RNASELI; RNS4I
Species Homo sapiens
Ensembl Gene ENSG00000164163
Encoded Proteins
IDBP-39793
ATP-binding cassette, sub-family E (OABP), member 1
IDBP-475234
ATP-binding cassette, sub-family E (OABP), member 1
IDBP-480571
ATP-binding cassette, sub-family E (OABP), member 1
IDBP-476001
ATP-binding cassette, sub-family E (OABP), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:145097932-145129179
Strand Forward strand
Band q31.21
Transcripts
ENST00000296577 ENSP00000296577
ENST00000502586 ENSP00000421250
ENST00000502803
ENST00000507193 ENSP00000422068
ENST00000506506
ENST00000504292 ENSP00000423415
ENST00000515678
ENST00000509593
ENST00000510321
ENST00000504683
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 24 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0008428 ribonuclease inhibitor activity
GO:0016887 ATPase activity
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006401 RNA catabolic process
GO:0009615 response to virus
GO:0016032 viral process
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000058355
View Gene Order
ENSBTAG00000019854
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.12013 Hs.605300 Hs.713456
RefSeq NM_001040876 NM_002940
HUGO
OMIM
CCDS CCDS34071
HPRD 03132
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca