Homo sapiens Gene: ABCE1
Summary
InnateDB Gene IDBG-39791.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCE1
Gene Name ATP-binding cassette, sub-family E (OABP), member 1
Synonyms ABC38; OABP; RLI; RNASEL1; RNASELI; RNS4I;
Species Homo sapiens
Ensembl Gene ENSG00000164163
Encoded Proteins
ATP-binding cassette, sub-family E (OABP), member 1
ATP-binding cassette, sub-family E (OABP), member 1
ATP-binding cassette, sub-family E (OABP), member 1
ATP-binding cassette, sub-family E (OABP), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:145097932-145129179
Strand Forward strand
Band q31.21
Transcripts
ENST00000296577 ENSP00000296577
ENST00000502586 ENSP00000421250
ENST00000502803
ENST00000507193 ENSP00000422068
ENST00000506506
ENST00000504292 ENSP00000423415
ENST00000515678
ENST00000509593
ENST00000510321
ENST00000504683
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 24 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0008428 ribonuclease inhibitor activity
GO:0016887 ATPase activity
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006401 RNA catabolic process
GO:0009615 response to virus
GO:0016032 viral process
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.12013 Hs.605300 Hs.713456
RefSeq NM_001040876 NM_002940
HUGO
OMIM
CCDS CCDS34071
HPRD 03132
IMGT
EMBL
GenPept
RNA Seq Atlas