Homo sapiens Gene: CDK5R1
Summary
InnateDB Gene IDBG-40195.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK5R1
Gene Name cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Synonyms CDK5P35; CDK5R; NCK5A; p23; p25; p35; p35nck5a;
Species Homo sapiens
Ensembl Gene ENSG00000176749
Encoded Proteins
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer\'s disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer\'s disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:32486619-32491256
Strand Forward strand
Band q11.2
Transcripts
ENST00000313401 ENSP00000318486
ENST00000584716 ENSP00000463654
ENST00000584792 ENSP00000464129
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 36 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0016534 cyclin-dependent protein kinase 5 activator activity
GO:0019901 protein kinase binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0045296 cadherin binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001764 neuron migration
GO:0006468 protein phosphorylation
GO:0007158 neuron cell-cell adhesion
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0007411 axon guidance
GO:0007413 axonal fasciculation
GO:0007420 brain development
GO:0008283 cell proliferation
GO:0009790 embryo development
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0021549 cerebellum development
GO:0021722 superior olivary nucleus maturation
GO:0021766 hippocampus development
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021819 layer formation in cerebral cortex
GO:0030182 neuron differentiation
GO:0030517 negative regulation of axon extension
GO:0031175 neuron projection development
GO:0032956 regulation of actin cytoskeleton organization
GO:0033136 serine phosphorylation of STAT3 protein
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0043525 positive regulation of neuron apoptotic process
GO:0045664 regulation of neuron differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048013 ephrin receptor signaling pathway
GO:0048511 rhythmic process
GO:0051726 regulation of cell cycle
GO:0061001 regulation of dendritic spine morphogenesis
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0090314 positive regulation of protein targeting to membrane
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031594 neuromuscular junction
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043292 contractile fiber
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Semaphorin interactions pathway
Axon guidance pathway
CRMPs in Sema3A signaling pathway
KEGG
Alzheimer's disease pathway
INOH
PID BIOCARTA
Lissencephaly gene (lis1) in neuronal migration and development [Biocarta view]
Deregulation of cdk5 in alzheimers disease [Biocarta view]
Regulation of ck1/cdk5 by type 1 glutamate receptors [Biocarta view]
Phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
PID NCI
Trk receptor signaling mediated by the MAPK pathway
Reelin signaling pathway
Glucocorticoid receptor regulatory network
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt Q15078
TrEMBL
UniProt Splice Variant
Entrez Gene 8851
UniGene Hs.500015 Hs.662611 Hs.714132
RefSeq NM_003885
HUGO HGNC:1775
OMIM 603460
CCDS CCDS11273
HPRD
IMGT
EMBL AY376350 BC020580 BT019573 CH471147 X80343
GenPept AAH20580 AAQ74776 AAV38380 CAA56587 EAW80227 EAW80228
RNA Seq Atlas 8851