Version 5.4
Homo sapiens Gene: PDXP
Summary
InnateDB Gene IDBG-402197.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDXP
Gene Name pyridoxal (pyridoxine, vitamin B6) phosphatase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000241360
Encoded Proteins
IDBP-6837
pyridoxal (pyridoxine, vitamin B6) phosphatase
IDBP-293796
pyridoxal (pyridoxine, vitamin B6) phosphatase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:37658727-37666934
Strand Forward strand
Band q13.1
Transcripts
ENST00000215904 ENSP00000215904
ENST00000403251 ENSP00000385336
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004647 phosphoserine phosphatase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0031072 heat shock protein binding
GO:0033883 pyridoxal phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0007088 regulation of mitosis
GO:0008152 metabolic process
GO:0030836 positive regulation of actin filament depolymerization
GO:0031247 actin rod assembly
GO:0032361 pyridoxal phosphate catabolic process
GO:0032465 regulation of cytokinesis
GO:0071318 cellular response to ATP
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
GO:0030496 midbody
GO:0031258 lamellipodium membrane
GO:0032154 cleavage furrow
GO:0032587 ruffle membrane
GO:0070062 extracellular vesicular exosome
GO:0070938 contractile ring
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
null
View Gene Order
ENSBTAG00000030255
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00750
Vitamin B6 metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B1AHD3
UniProt Splice Variant
Entrez Gene 57026
UniGene Hs.609275 Hs.632762
RefSeq NM_020315
HUGO HGNC:30259
OMIM 609246
CCDS CCDS13953
HPRD
IMGT
EMBL Z83844
GenPept
RNA Seq Atlas 57026

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca