Version 5.4
Homo sapiens Gene: TDGF1
Summary
InnateDB Gene IDBG-409017.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TDGF1
Gene Name teratocarcinoma-derived growth factor 1
Synonyms CR; CRGF; CRIPTO
Species Homo sapiens
Ensembl Gene ENSG00000241186
Encoded Proteins
IDBP-30593
teratocarcinoma-derived growth factor 1
IDBP-586134
teratocarcinoma-derived growth factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:46574555-46626543
Strand Forward strand
Band p21.31
Transcripts
ENST00000296145 ENSP00000296145
ENST00000444264
ENST00000505797
ENST00000493282
ENST00000471721
ENST00000459867
ENST00000542931 ENSP00000446375
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0001763 morphogenesis of a branching structure
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0007369 gastrulation
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0008595 anterior/posterior axis specification, embryo
GO:0009790 embryo development
GO:0009948 anterior/posterior axis specification
GO:0009966 regulation of signal transduction
GO:0010595 positive regulation of endothelial cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0030154 cell differentiation
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030879 mammary gland development
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0043066 negative regulation of apoptotic process
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048146 positive regulation of fibroblast proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0055007 cardiac muscle cell differentiation
GO:0060070 canonical Wnt signaling pathway
GO:0071346 cellular response to interferon-gamma
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071364 cellular response to epidermal growth factor stimulus
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0009986 cell surface
GO:0016324 apical plasma membrane
GO:0019897 extrinsic component of plasma membrane
GO:0031225 anchored component of membrane
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000032494
View Gene Order
Pathways
NETPATH
REACTOME
REACT_111059
Regulation of signaling by NODAL pathway
REACT_111057
Signaling by NODAL pathway
REACT_111045
Developmental Biology pathway
REACT_200812
Transcriptional regulation of pluripotent stem cells pathway
REACT_200759
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway
KEGG
INOH
PID NCI
glypican_1pathway
Glypican 1 network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.385870 Hs.592361 Hs.679623
RefSeq NM_001174136 NM_003212
HUGO
OMIM
CCDS CCDS2742 CCDS54575
HPRD 01757
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca