Homo sapiens Gene: STAT2
Summary
InnateDB Gene IDBG-40906.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAT2
Gene Name signal transducer and activator of transcription 2, 113kDa
Synonyms ISGF-3; P113; STAT113;
Species Homo sapiens
Ensembl Gene ENSG00000170581
Encoded Proteins
signal transducer and activator of transcription 2, 113kDa
signal transducer and activator of transcription 2, 113kDa
signal transducer and activator of transcription 2, 113kDa
signal transducer and activator of transcription 2, 113kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
STAT2 is part of STAT-containing transcription factor, the alpha-interferon-induced ISGF3, that is composed of a STAT1:2 heterodimer and a weak DNA-binding protein, IRF9.
STAT2 is a critical transactivator component of the interferon-stimulated gene factor 3 (ISGF3) complex that drives the expression of many interferon (IFN)-inducible genes.
A loss-of-function mutation in STAT2 is associated with increased susceptibility to childhood viral diseases.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Transcriptional activation of Adar by IFN occurs in the absence of Stat1 by a non-canonical Stat2-dependent pathway.
Entrez Gene
Summary The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56341597-56360155
Strand Reverse strand
Band q13.3
Transcripts
ENST00000314128 ENSP00000315768
ENST00000418572 ENSP00000387354
ENST00000556539
ENST00000557235 ENSP00000450751
ENST00000555488
ENST00000557199
ENST00000555519
ENST00000557252
ENST00000556140
ENST00000557156
ENST00000557417
ENST00000555646 ENSP00000450985
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 45 [view]
Protein-DNA 33 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007259 JAK-STAT cascade
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Regulation of IFNA signaling pathway
Interferon Signaling pathway
Immune System pathway
KEGG
Chemokine signaling pathway pathway
Osteoclast differentiation pathway
Jak-STAT signaling pathway pathway
Hepatitis C pathway
INOH
IFN alpha signaling pathway
JAK STAT pathway and regulation pathway
PID BIOCARTA
Ifn alpha signaling pathway [Biocarta view]
PID NCI
CXCR4-mediated signaling events
IL27-mediated signaling events
Cross-References
SwissProt P52630
TrEMBL B4DLC8 G3V319 Q6LD48 R9QE65 R9QG81
UniProt Splice Variant
Entrez Gene 6773
UniGene Hs.530595
RefSeq NM_005419 NM_198332 XM_005269108 XM_005269109 XM_005269110 XM_005269111
HUGO HGNC:11363
OMIM 600556
CCDS CCDS55836 CCDS8917
HPRD
IMGT
EMBL AC025574 AK296939 AK296940 AY525126 BC051284 CH471054 JX178204 JX178205 JX178206 JX178207 JX178208 JX178209 JX178210 JX178211 JX178213 JX178214 JX178215 JX178216 JX178217 JX178218 JX178219 JX178220 JX178223 JX178224 JX178225 JX178227 JX178232 JX178234 JX178236 JX178237 JX178238 JX178239 JX178240 JX178241 JX178242 JX178243 JX178245 JX178246 JX178247 JX178249 JX178250 JX178251 JX178252 JX178254 JX178255 JX178256 JX178257 JX178258 JX178260 JX178262 JX178263 JX178264 JX178266 JX178269 JX178273 M97934 S81491 U18671
GenPept AAA98760 AAB36225 AAB36226 AAB36227 AAH51284 AAS00091 AFM91192 AFM91193 AFM91194 AFM91195 AFM91197 AFM91198 AFM91199 AFM91200 AFM91202 AFM91203 AFM91204 AFM91205 AFM91206 AFM91207 AFM91208 AFM91209 AFM91212 AFM91213 AFM91214 AFM91216 AFM91221 AFM91223 AFM91225 AFM91226 AFM91227 AFM91228 AFM91229 AFM91230 AFM91231 AFM91232 AFM91234 AFM91235 AFM91236 AFM91238 AFM91239 AFM91240 AFM91241 AFM91243 AFM91244 AFM91245 AFM91246 AFM91247 AFM91249 AFM91251 AFM91252 AFM91253 AFM91255 AFM91258 AFM91262 BAG59489 BAG59490 EAW96934 EAW96935 EAW96937
RNA Seq Atlas 6773