Bos taurus Gene: STAT2 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-635999.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | STAT2 | ||||||||||||||
Gene Name | signal transducer and activator of transcription 2 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000004380 | ||||||||||||||
Encoded Proteins |
signal transducer and activator of transcription 2, 113kDa
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||
Summary |
[Homo sapiens] STAT2 is part of STAT-containing transcription factor, the alpha-interferon-induced ISGF3, that is composed of a STAT1:2 heterodimer and a weak DNA-binding protein, IRF9.
[Homo sapiens] STAT2 is a critical transactivator component of the interferon-stimulated gene factor 3 (ISGF3) complex that drives the expression of many interferon (IFN)-inducible genes.
[Homo sapiens] A loss-of-function mutation in STAT2 is associated with increased susceptibility to childhood viral diseases.
[Mus musculus] Transcriptional activation of Adar by IFN occurs in the absence of Stat1 by a non-canonical Stat2-dependent pathway.
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Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170581:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 5:57318819-57333404 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH |
EGFR1 pathway
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REACTOME |
Regulation of IFNA signaling pathway
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
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KEGG |
Jak-STAT signaling pathway pathway
Chemokine signaling pathway pathway
Osteoclast differentiation pathway
Hepatitis C pathway
Jak-STAT signaling pathway pathway
Chemokine signaling pathway pathway
Osteoclast differentiation pathway
Hepatitis C pathway
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INOH |
JAK STAT pathway and regulation pathway
IFN alpha signaling pathway
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PID NCI |
CXCR4-mediated signaling events
IL27-mediated signaling events
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Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | E1B8Z4 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 511023 | ||||||||||||||
UniGene | |||||||||||||||
RefSeq | NM_001205689 XM_005206561 | ||||||||||||||
HUGO | HGNC:11363 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | DAAA02013529 | ||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | 511023 | ||||||||||||||